Results 261 to 270 of about 4,095,028 (342)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Transplant Outcomes After Exposure of Deceased Kidney Donors to Contrast Medium. [PDF]

Transplantation
Chotkan KA, Hilbrands LB, Putter H, Konjin C, Schaefer B, Beenen LFM, Pol RA, Braat AE.   +7 more
europepmc   +1 more source

Efficacy of Test Injection Technique with a Small Amount of Contrast Medium on Contrast Enhanced MR Angiography of the Renal Artery

, 2000
M Takahashi, Mitsutoshi Arata, Makoto Hasegawa, Naohiko Mori, Minoru YAMANOKUCHI, Tadashi Matsubara   +5 more
openalex   +2 more sources

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Pressure waveform analysis for occlusion assessment significantly reduces contrast medium use in cryoballoon pulmonary vein isolation. [PDF]

J Interv Card Electrophysiol
Sciacca V, Fink T, Winnik S, Hamriti ME, Guckel D, Didenko M, Mörsdorf M, Braun M, Khalaph M, Imnadze G, Sommer P, Sohns C.   +11 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Halved contrast medium dose coronary dual-layer CT-angiography - phantom study of tube current and patient characteristics. [PDF]

Int J Cardiovasc Imaging
Kristiansen CH, Tetteroo PM, Dobrolinska MM, Lauritzen PM, Velthuis BK, Greuter MJW, Suchá D, de Jong PA, van der Werf NR.   +8 more
europepmc   +1 more source

Successful Removal of a Left Main Coronary Artery Thrombus Induced by Vasospasm of the Aorta After the Injection of Contrast Medium

, 2001
Toshihiko Yamasa, Shiro Hata, Atsuki Fukae, Akiyo Ninomiya, Satoshi Ikeda, Yoshiyuki Miyahara, Shigeru Kohno   +6 more
openalex   +2 more sources

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source