Results 181 to 190 of about 1,707,949 (259)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The impact of various daily disposable contact lens materials on contrast sensitivity. [PDF]

Arq Bras Oftalmol
Tabakci BN, Güler SD, Varan G, Aksöz P, Yildirim Y.   +4 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Lateral inhibition in V1 controls neural and perceptual contrast sensitivity. [PDF]

Nat Neurosci
Del Rosario J, Coletta S, Kim SH, Mobille Z, Peelman K, Williams B, Otsuki AJ, Del Castillo Valerio A, Worden K, Blanpain LT, Lovell L, Choi H, Haider B.   +12 more
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Central Contrast Sensitivity as an Outcome Measure in Randomized Controlled Trials in Glaucoma-A Systematic Review. [PDF]

Life (Basel)
Sverstad A, Møller JR, Virgili G, Azuara-Blanco A, Freiberg J, Ahrensberg S, Kristianslund O, Petrovski G, Kolko M.   +8 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Contrast Sensitivity Impairment Is Associated With Limitations of Physical Functioning and Activities of Daily Living Among Older Adults. [PDF]

J Aging Health
Kumar N, Kabeto M, Galecki AT, Karvonen-Gutierrez CA, Ehrlich JR.   +4 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Long-Term Evaluation of Contrast Sensitivity and Vision Quality for High and Extreme High Myopia After EVO ICL Implantation. [PDF]

Clin Ophthalmol
Ma Y, Fukuyama T, Cao J, Ye Y, Niu L, Yao P, Wang X, Zhou X, Zhao J.   +8 more
europepmc   +1 more source