Results 11 to 20 of about 230,853 (205)

The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence. [PDF]

Mol Oncol
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Flores NG, Fernández-Aroca DM, Garnés-García C, Domínguez-Calvo A, Jiménez-Suárez J, Sabater S, Fernández-Aroca P, Andrés I, Cimas FJ, de Cárcer G, Belandia B, Palmero I, Huertas P, Ruiz-Hidalgo MJ, Sánchez-Prieto R.   +14 more
europepmc   +2 more sources

Effect of high‐volume insecticide spraying on sand fly vectors in household gardens in Spain

Zoonoses and Public Health, Volume 70, Issue 6, Page 511-522, September 2023., 2023
Abstract This study investigated the efficacy of high‐volume spraying with the adulticide α‐cypermethrin alone and in combination with the larvicide diflubenzuron on the density of sand flies in gardens of three detached households in periurban areas in southeast Spain.
María Ortuño, Clara Muñoz‐Hernández, José Risueño, Zarima Jumakanova, Alessia Farinella, Slavica Vaselek, Luis J. Bernal, Pedro F. Sánchez‐López, Francisco Collantes, Rocío Ruiz de Ybáñez, Carlos Martínez‐Carrasco, Pedro Pérez‐Cutillas, Eduardo Berriatua   +12 more
wiley   +1 more source

Volcanic Early Warning Using Shannon Entropy: Multiple Cases of Study

Journal of Geophysical Research: Solid Earth, Volume 128, Issue 6, June 2023., 2023
Abstract The search for pre‐eruptive observables that can be used for short‐term volcanic forecast remains a scientific challenge. Pre‐eruptive patterns in seismic data are usually identified by analyzing seismic catalogs (e.g., the number and types of recorded seismic events), the evolution of seismic energy, or changes in the tensional state of the ...
Pablo Rey‐Devesa, Carmen Benítez, Janire Prudencio, Ligdamis Gutiérrez, Guillermo Cortés‐Moreno, Manuel Titos, Ivan Koulakov, Luciano Zuccarello, Jesús M. Ibáñez   +8 more
wiley   +1 more source

Language in the process of labour market rationalisation: A sociohistorical approach across twentieth‐century Spain

Journal of Sociolinguistics, Volume 27, Issue 2, Page 115-135, April 2023., 2023
Abstract This article analyses the role of linguistic skills in the process of defining professional classifications in Spain during 1919–1980. The aim is to determine the social evaluation of the skills involved. To retrace the classifications, a total of 114 official documents were examined, establishing a chronological division into three major ...
Amado Alarcón Alarcón, Maria Jesús Muiños Villaverde, Maria de los Ángeles Serrano Alonso, Josiah Heyman   +3 more
wiley   +1 more source

The emergent role of mitochondrial RNA modifications in metabolic alterations

WIREs RNA, Volume 14, Issue 2, March/April 2023., 2023
Mitochondrial RNA modifications in rRNA, tRNA, and mRNA may disrupt the proper functioning of energetic metabolism, increasing the risk of metabolic diseases. Abstract Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than
Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González   +6 more
wiley   +1 more source

Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport

Journal of Pineal Research, Volume 73, Issue 3, October 2022., 2022
Abstract The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS) levels, but how melatonin induces this ROS generation is unknown. In the present study, we aimed to elucidate the two seemingly opposing actions of melatonin regarding its relationship with free radicals.
Javier Florido, Laura Martinez‐Ruiz, César Rodriguez‐Santana, Alba López‐Rodríguez, Agustín Hidalgo‐Gutiérrez, Cécile Cottet‐Rousselle, Frédéric Lamarche, Uwe Schlattner, Ana Guerra‐Librero, Paula Aranda‐Martínez, Darío Acuña‐Castroviejo, Luis C. López, Germaine Escames   +12 more
wiley   +1 more source

El principio de legalidad: una necesaria restricción a la aplicación de la doctrina de los actos propios en la contratación estatal

Revista Digital de Derecho Administrativo, 2016
La jurisprudencia nacional ha aplicado la regla “contra factum proprium quis venire non potest”, en el ámbito de la contratación estatal, con fundamento en el principio de la buena fe.
Luisa Alexandra Torres-Acosta
doaj   +1 more source

A Water Soluble and Solid‐State Molecular Solar Thermal (MOST) System as Renewable Solar Fuel

Angewandte Chemie, Volume 137, Issue 43, October 20, 2025.
“A new series of highly water soluble norbornadienes has been synthesized and characterized as molecular solar thermal (MOST) systems in gram scale. Particularly, concentrated solutions (1 M) and solid‐state heat release showed a thermal heat release of 7.5 and 39.6 K, respectively, with full reversibility in both cases.
Sara Hernáez‐Troya, Nil Sanosa, Alberto Giménez‐Gómez, Víctor Pozo‐Gavara, Diego Sampedro, Ignacio Funes‐Ardoiz   +5 more
wiley   +2 more sources

La planeación en los contratos de obra pública en Colombia ¿principio, deber o requisito? Obligatoriedad y consecuencias de su inaplicación

Opinión Jurídica, 2019
La indagación acerca del principio de planeación en el contrato estatal de obra pública constituye el objetivo de este escrito. De él tratan la jurisprudencia y la doctrina administrativa y lo derivan de las normas legales y de los principios que la Ley ...
Marissa Rúa Flechas, Juan Carlos Arbeláez Restrepo, Harol Castro Beltrán   +2 more
doaj   +1 more source

Declaratoria de caducidad del contrato de concesión y responsabilidad del Estado: a propósito de la sentencia de la Corte Suprema de Justicia del 20 de octubre de 1898

Revista Digital de Derecho Administrativo, 2020
El presente artículo tiene por objeto explicar, a partir de un método histórico jurídico e inductivo, la importancia de la sentencia de la Corte Suprema de Justica del 20 de octubre de 1898, en la que se condena al Estado por el decreto que da por ...
Hugo Arenas Mendoza
doaj   +1 more source