Results 1 to 10 of about 1,374 (172)

Advancing precision oncology through systematic germline and tumor genetic analysis: The oncogenetic point of view on findings from a prospective multicenter clinical trial of 666 patients

Cancer Medicine, 2023
Introduction With the emergence of targeted therapies, there is a need to accurately identify more tumor biomarkers. The EXOMA trial was designed to offer tumor and germline exome sequencing (ES) to patients with solid malignant tumors and facing ...
Benoit Mazel, Geoffrey Bertolone, Amandine Baurand, Elodie Cosset, Caroline Sawka, Marion Robert, Elodie Gautier, Allan Lançon, Manon Réda, Laure Favier, Valentin Dérangère, Corentin Richard, Christine Binquet, Romain Boidot, Vincent Goussot, Juliette Albuisson, François Ghiringhelli, Laurence Faivre, Sophie Nambot   +18 more
doaj   +2 more sources

Fonctions de la sensorialité dans la prise en charge thérapeutique de l’autisme infantile [PDF]

Revista Latinoamericana de Psicopatologia Fundamental, 2023
La sensorialité tient plusieurs fonctions dans l’élaboration psychique de l’individu autiste et dans son évolution psychique au cours de sa prise en charge thérapeutique.
Sarah Makhlouf, Solange Carton, Marie Dessons   +2 more
doaj   +1 more source

FOXO1 or not FOXO1: that is the question. [PDF]

Cancer Commun (Lond)
Cancer Communications, Volume 45, Issue 1, Page 43-45, January 2025.
Marchais M, Mangeney M.
europepmc   +2 more sources

Antagonisation of Prokineticin Receptor-2 Attenuates Preeclampsia Symptoms. [PDF]

J Cell Mol Med
ABSTRACT Preeclampsia (PE) is the most threatening pathology of human pregnancy. Placenta from PE patients releases harmful factors that contribute to the exacerbation of the disease. Among these factors is the prokineticin1 (PROK1) and its receptor, PROKR2 that we identified as a mediators of PE.
Sergent F, Vaiman D, Raia-Barjat T, Younes H, Marquette C, Desseux M, Nahed RA, Kieu TL, Dung NV, Keck M, Hoffmann P, Murthi P, Benharouga M, Alfaidy N.   +13 more
europepmc   +2 more sources

Coopération judiciaire et lutte contre l’impunité des crimes internationaux et violations des droits de l’homme dans la région des Grands Lacs

KAS African Law Study Library, 2022
Pour assurer le respect des droits de l’homme et du droit international humanitaire et lutter ainsi contre l’impunité, les États doivent mettre en place des mécanismes de coopération judicaire, car les moyens dont dispose chaque pays isolément pour faire
Pacifique Muhindo Magadju
doaj   +1 more source

Témoignage - De la production des connaissances à leur mise en œuvre dans les programmes d’actions [PDF]

Sciences, Eaux & Territoires, 2019
Comment les techniciens et les gestionnaires perçoivent et s’emparent des connaissances produites par les scientifiques ? Est-ce que ces connaissances guident leurs actions ? Comment se fait l’interface entre ces deux communautés d’acteurs ?
MORET, Catherine
doaj   +3 more sources

Intrinsic cancer cell phosphoinositide 3‐kinase δ regulates fibrosis and vascular development in cholangiocarcinoma

Liver International, Volume 43, Issue 12, Page 2776-2793, December 2023., 2023
Abstract Background & Aims The class I‐ phosphatidylinositol‐3 kinases (PI3Ks) signalling is dysregulated in almost all human cancers whereas the isoform‐specific roles remain poorly investigated. We reported that the isoform δ (PI3Kδ) regulated epithelial cell polarity and plasticity and recent developments have heightened its role in hepatocellular ...
Vanessa Bou Malham, Nassima Benzoubir, Javier Vaquero, Christophe Desterke, Jean Agnetti, Pei Xuan Song, Ester Gonzalez‐Sanchez, Ander Arbelaiz, Sophie Jacques, Emanuel Di Valentin, Souad Rahmouni, Tuan Zea Tan, Didier Samuel, Jean Paul Thiery, Mylène Sebagh, Laura Fouassier, Ama Gassama‐Diagne   +16 more
wiley   +1 more source

The Sunrise of Tertiary Lymphoid Structures in Cancer. [PDF]

Immunol Rev
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Rochefort J, Marodon G, Teillaud JL, Dieu-Nosjean MC.   +3 more
europepmc   +2 more sources

Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2‐positive cancers

Molecular Oncology, Volume 17, Issue 10, Page 1981-1999, October 2023., 2023
The tyrosine kinase receptor HER2 is a major oncogene in multiple cancers. We identified ebselen oxide as a new allosteric inhibitor of HER2. Ebselen oxide maintains HER2 in a catalytically repressed state by targeting the ezrin/radixin/moesin (ERM)‐binding motif in the juxtamembrane region of HER2.
Lucas Blasquez, Haniaa Bouzinba‐Segard, Sandrine Bourdoulous, Camille Faure   +3 more
wiley   +1 more source

Immunoglobulin E‐specific allergens against leaf in serum of dogs with clinical features of grass leaf allergy

Veterinary Dermatology, Volume 34, Issue 5, Page 393-403, October 2023., 2023
Background – Grass leaf has been suspected to cause immunoglobulin (Ig)E‐mediated immediate hypersensitivity reactions both in humans and in dogs. However, most studies in this area are case control studies without in vitro data showing the involvement of IgE in the reaction.
Ken Mason, Janet Davies, Merja Ruutu
wiley   +1 more source