Results 151 to 160 of about 6,056,553 (315)

A Robust Estimation of the Effects of Taxation on Charitable Contributions [PDF]

While many studies find that the tax-price elasticity of giving exceeds unity, several recent studies find the contrary. This is important because it can be shown that if the elasticity exceeds one, then allowing taxpayers to deduct charitable giving ...
Ralph Bradley, Robert McClelland, Steven Holden   +2 more
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Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Defining contributions: inspiration driving original research.

, 2012
Defining Contributions: Inspiration Driving Original Research was a postgraduate conference held at Nottingham Trent University on 18th May 2012. This conference was part of the Research Practice Course (RPC) in which students engage with research ...
Dallabona, Alice, Wijetunge, Nishan, Coulbert, Esme, Abbas, Jabbar, Gamble, Rebecca, Roddis, Melissa, Silcock, Neil, Blood, Kate   +7 more
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Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Sequential versus Simultaneous Contributions to Public Goods: Experimental Evidence [PDF]

We report an experiment comparing sequential and simultaneous contributions to a public good in a quasi-linear two-person setting (Varian, Journal of Public Economics, 1994).
Simon Gaechter, Elke Renner, Martin Sefton, Daniele Nosenzo   +3 more
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Introduction to the Special Issue on Emerging Trends of Systemic Family Therapy Around the World. [PDF]

J Marital Fam Ther
Nadan Y, Guanaes-Lorenzi C, Sesma-Vazquez M.   +2 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Contributions Agency framework document 1994

, 1994
SIGLEAvailable from British Library Document Supply Centre- DSC:4032.11906(1994) / BLDSC - British Library Document Supply CentreGBUnited ...
Contributions Agency (United Kingdom), Dudgeon, I   +1 more
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