Results 221 to 230 of about 10,569,958 (299)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The private solution trap in collective action problems across 34 nations. [PDF]

Proc Natl Acad Sci U S A
Malthouse E, Pilgrim C, Sgroi D, Accerenzi M, Alfonso A, Ashraf RU, Baard M, Banerjee S, Belianin A, Bhattacharjee S, Bhattacharya M, Brañas-Garza P, Cárdenas JC, Carriquiry M, Choi S, Clochard GJ, Denzon EE, Dessoulavy-Sliwinski B, Dini G, Dong L, Ertl A, Exadaktylos F, Filiz-Ozbay E, Flecke SL, Galeotti F, Garcia-Muñoz T, Hanaki N, Hollard G, Horn D, Huang L, İriş D, Kiss HJ, Koch J, Kovářík J, Kwarteng OKB, Lange A, Leites M, Leung TH, Lim W, Morren M, Nockur L, Okyere CY, Oudah M, Ozkes AI, Page L, Park J, Pfattheicher S, Proestakis A, Ramos C, Ramos-Sosa M, Ashraf MS, Sanjaya MR, Schwaiger R, Sene O, Song F, Spycher S, Staněk R, Tanchingco N, Tavoni A, Te Velde V, Vázquez-De Francisco MJ, Visser M, Wang JT, Wang W, Weng WC, Werner K, Wijayanti A, Winkler R, Wooders J, Ying L, Zhen W, Hills T.   +71 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Correction: Recent advances in MOF-based single-atom photocatalysts for CO₂ to solar fuel conversion under sunlight irradiation. [PDF]

Chem Sci
Majeed A, Duong MK, Nguyen VD, Do TO.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis of High-Field-Induced Processes with Enthalpy Release in Martensite-Austenite MnCo(Fe)(GeSi) Alloys: Solving PPMS Artifact and Recovery of Heat Capacity. [PDF]

Materials (Basel)
Vidal-Crespo A, Romero FJ, Ipus JJ, Blázquez JS.   +3 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A unified ab initio theory of spin-phonon relaxation and decoherence uncovers fast dephasing in magnetic molecules. [PDF]

Sci Adv
Lunghi A.
europepmc   +1 more source

Telecommunications Policies in Comparison: Industrial Policy Indicators; Research Project on behalf of Deutsche Telekom AG [PDF]

Christian Wey. Based on Contributions by Michel Berne, Daniel Nepelski, Pio Baake, Vanessa von Schlippenbach et al.   +3 more
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