Results 101 to 110 of about 27,416,311 (310)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of Control Science and Engineering, 2023 Journal of Control Science and Engineering
doaj +1 more source
Innovation in EU merger control: walking the talk [PDF]
European Union policymakers have in principle put innovation at the heart of competitiveness, in particular in the Europe 2020 strategy. But in merger control, assessments of the innovation effects of mergers are inadequate, even though mergers and ...
Reinhilde Veugelers
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Control Science and Engineering, 2023 Journal of Control Science and Engineering
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Journal of Control Science and Engineering, 2023 Journal of Control Science and Engineering
doaj +1 more source
, 2017 Research provides the basis for scientific discovery and advancements in all areas of science. The process of discovery involves countless repetitions of the identical experiment in order to make a claim about the topic in question. In order to properly conduct an experiment that is similar or the same to one already executed, all of the variables must
openaire +2 more sources
Antilock braking control using robust control approach [PDF]
, 2006 The aims of this study are to establish the mathematical model and the robust control technique for an Antilock Braking System (ABS). The ABS have been developed to reduce tendency of wheel lock up and to improve vehicle control during sudden braking ...
Hamzah, Norhazimi
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source