Results 141 to 150 of about 6,764,216 (308)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Comparison of Antimicrobial Stewardship and Infection Prevention and Control Activities and Resources Between Low-/Middle- and High-income Countries. [PDF]

Pediatr Infect Dis J, 2022
Villanueva P, Coffin SE, Mekasha A, McMullan B, Cotton MF, Bryant PA.   +5 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Safely resuming neglected tropical disease control activities during COVID-19: Perspectives from Nigeria and Guinea. [PDF]

PLoS Negl Trop Dis, 2021
McKay S, Shu'aibu J, Cissé A, Knight A, Abdullahi F, Ibrahim A, Madaki S, Genovezos C, McCoy K, Downs P, Kabore A, Adamu H, Gobir IB, Chaitkin M, Standley CJ.   +14 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Evidence on article 5.3 of FCTC (tobacco industry interference in tobacco control activities) in India- a qualitative scoping study. [PDF]

BMC Public Health, 2021
Goel S, Kar SS, Verma M, Sivanantham P, Naik BN, Gupta D.   +5 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Assessment of the oral cancer control activities through care seeking behavior of hospital attendees and their level of awareness. [PDF]

J Oral Biol Craniofac Res, 2021
Amarasinghe H, Rathnapriya M, Abeysundara A, Jayaweera S, Jayathilake A, Jayasinghe R.   +5 more
europepmc   +1 more source

Development of an externally powered prosthetic hook for amputees [PDF]

The powered hook with trigger finger appears to be a useful adaptation of a terminal device for an amputee when performing vocational activities involving the use of a powered tool requiring a trigger control.
Allen, J. R., Bontrager, E. L., Karchak, A., Jr.   +2 more
core   +1 more source

Applying FRAM to the construction of concrete frame structures [PDF]

, 2018
So far the FRAM has been applied to different sectors of high risk and complexity such as aviation, including air traffic control, health care, nuclear power plants, chemical and petrochemical industry, railways, maritime sector...
Rubio-Romero, Juan Carlos
core