Results 51 to 60 of about 291,024 (349)
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2023 A system with distributed parameters in its mechanical part is considered. Examples of such a system are given. The reason for taking into account the distribution of parameters in such systems is indicated.
A. P. Korneev +2 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Comparison of the operation of milking machine control valves and a newly designed regulating device
Research in Agricultural Engineering, 2003 One of the basic demands for milking machines is to maintain a constant vacuum level if air consumption by milking machine is changed. The author designed a device with reducing valve for vacuum level regulation and a simultaneous vacuum pump control ...
J. Fryč
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
CONTROL DEVICE OF COMMON RAIL TYPE FUEL INJECTION SYSTEM [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2009 The valve of piezonozzle performance control in the «Common rail» diesel engine injection system is considered in the given article. The control device of the oil injection system with valves based on direct and inverse piezoelectric effect that enables ...
O. Strilets
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Design of mechanism for assisting walking motion driven by user's own arm
Nihon Kikai Gakkai ronbunshu, 2017 In recent years, many assist devices have been developing to enable the users to walk by an electric control system. However, introducing an electric control system makes the price rise of the device.
Jun NANGO +5 more
doaj +1 more source