Results 211 to 220 of about 13,485,994 (266)
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
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Postmodernism and Control Engineering
2009Modernism is defined by some important features: rationalism (the belief in knowledge through reason), empiricism (the belief in knowledge through experience) and materialism (the belief in a purely physical universe). Postmodernism is a recent movement and a reaction to modernism.
Valentina Emilia Balas +1 more
openaire +2 more sources
Microprocessors and Microsystems, 1981
Abstract Many studies on the automotive engine as a control system have been investigated in order to meet emission regulations and to improve the fuel economy. Sophisticated control systems which, up to the introduction of the microcomputer were a problem, are now easy to realize. In this paper, the fuel supply and ignition timing are considered as
S. Aono, Y. Hata
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Abstract Many studies on the automotive engine as a control system have been investigated in order to meet emission regulations and to improve the fuel economy. Sophisticated control systems which, up to the introduction of the microcomputer were a problem, are now easy to realize. In this paper, the fuel supply and ignition timing are considered as
S. Aono, Y. Hata
openaire +1 more source
BIOTECHNOLOGY AND CONTROL ENGINEERING
IFAC Proceedings Volumes, 1983Abstract The application of control engineering to biotechnology is a complex field requiring deep knowledge of both fundamental biological processes and highly developed technology. The possibilities of monitoring the course of a microbiological process by measuring changes in the culture liquid are limited.
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Control and Financial Engineering
2003The paper provides a review of the basics of financial engineering, with a few examples. We emphasize connections with control theory in a broad sense rather than with stochastic control theory in particular, and the reader is not assumed to be versed in stochastic processes.
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