Results 41 to 50 of about 4,537,045 (350)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
V-Model Role Engineering [PDF]
The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
core
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Fighter aircraft flight control technology design requirements [PDF]
, 1984 The evolution of fighter aircraft flight control technology is briefly surveyed. Systems engineering, battle damage considerations for adaptive flutter suppression, in-flight simulation, and artificial intelligence are briefly ...
Nelson, W. E., Jr.
core +1 more source
Quantum control in infinite dimensions
, 2003 Accurate control of quantum evolution is an essential requirement for quantum state engineering, laser chemistry, quantum information and quantum computing.
Ball +7 more
core +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Autonomous Boat Control Software Design Using Model-Based Systems Engineering [PDF]
, 2019 While there is considerable buzz about self-driving cars, self-driving boats are actually more fully developed. The Boat Hardware Control Platform Team was tasked with developing a fleet of small autonomous boats that travel to a destination while ...
Nelson, Noah
core +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Embedded Software Design for Mechatronic Systems [PDF]
, 2003 This research project is motivated by the fact that nowadays it is impossible to separate control engineering from software engineering. Besides that both of them can be found in definitions of mechatronics, this project deals with exploitation and ...
Broenink, Jan F. +2 more
core +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source