Results 161 to 170 of about 21,187,973 (294)

When Bioengineering Met Artificial Intelligence: From Machine Learning to Intelligent Bioengineering Systems. [PDF]

Bioengineering (Basel)
Giansanti D.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

APPLYING MODEL-BASED SYSTEMS ENGINEERING TO BASELINE HUGHES SALVO MODEL FOR FUTURE DEVELOPMENT

This capstone project explores how model-based systems engineering (MBSE) principles can be applied to facilitate modifications to the Hughes Salvo model and how the development of a baseline set of systems engineering artifacts can aid in future ...
Doerr, Christopher M., Johnson, Feona Mae L., Ward, Josiah H., Crooks, Keithley, Johnson, Irah   +4 more
core   +1 more source

Causal Explanation from a Conceptual Engineering Perspective: Non-Reductionism, Precision, and Pluralism. [PDF]

Acta Biotheor
Lee J, Ross LN.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

<i>Legionella</i> in operational healthcare water systems: a case-based approach to investigation, interpretation, and control. [PDF]

Infect Prev Pract
Ali S, Dolan AM, Lapthorne S, Doyle M.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Microbial Biotechnology at the Frontiers of Innovation: Engineering Solutions for Health, Industry and Sustainability. [PDF]

Microb Biotechnol
Bernal P, Ramos JL.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

3D Genome Engineering Using CRISPR/dCas Systems. [PDF]

Int J Mol Sci
Mamaeva NY, Yakovlev VA, Kristovskiy NV, Feskin PG, Vinnikov RS, Oleinikov PD, Shmakov SA, Shaitan KV, Kirpichnikov MP, Shaytan AK.   +9 more
europepmc   +1 more source