Results 221 to 230 of about 7,679,447 (385)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Use of floater valves to provide a constant inlet flow in furrow irrigation. [PDF]

Sci Rep
Ostad-Ali-Askari K, Raeisi-Vanani H, Kianmehr P.   +2 more
europepmc   +1 more source

Model-based control and optimization of large scale physical systems - Challenges in reservoir engineering

, 2009
Paul M.J. Van den Hof, J. D. Jansen, О.H. Bosgra, Gijs van Essen   +3 more
openalex   +2 more sources

A control systems engineering approach for adaptive behavioral interventions: illustration with a fibromyalgia intervention [PDF]

, 2014
Sunil Deshpande, Daniel E. Rivera, Jarred Younger, Naresh N. Nandola   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Performance enhancement of a wind driven PMSG using an artificial neural network based nonlinear backstepping controller. [PDF]

PLoS One
Dani A, Mekrini Z, Mrabet ME, Boulaala M, Chojaa H, Al-Sumaiti AS, Mossa MA.   +6 more
europepmc   +1 more source

Command and Control System and Fire Control System Overview of an Engineering Protection System [PDF]

Proceedings of the 2016 7th International Conference on Mechatronics, Control and Materials (ICMCM 2016), 2016
Ning Cai, Zhi Yi, Wenxuan Xu, Peichao Zhang   +3 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comparative optimization of PIDN and fractional order controllers for a quarter car active suspension system using recent metaheuristic algorithms. [PDF]

Sci Rep
Özbilgin F, Mengi OÖ, Wadood A, Güven AF, Park H.   +4 more
europepmc   +1 more source

Integration of Systems Engineering-based Paradigms for the Scheduling and Control of an Experimental Hot-rolling Mill

, 2009
Miguel Gama, Mahdi Mahfouf
openalex   +2 more sources