Results 31 to 40 of about 37,401 (266)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Study of fiscal decentralization, macroeconomic stability and regional growth in Indonesia
Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2021 Indonesia has been implementing fiscal decentralization since 2001. In theory, fiscal decentralization affected macroeconomic stability and economic growth—this study using data panels at the provincial level from 2010 to 2013.
Joko Tri Haryanto, Rita Helbra Tenrini
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Los principios rectores del derecho tributario
Nuevo Derecho, 2014 La necesidad de diseñar y coordinar la política fiscal del Estado, encuentra en el principio de legalidad un sólido fundamento constitucional, especialmente en cuanto tiene que ver con las competencias que puede atribuirse a las entidades territoriales,
María Bibiana Hincapié Gómez
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
La Nueva era del Control Fiscal Tributario con los documentos electrónicos en Colombia
JusticiaObjetivo: la presente pesquisa tiene como propósito evidenciar la importancia que ha tenido el uso de documentos electrónicos en el cumplimiento de la función fiscalizadora por parte del Estado.
Sergio Luis Mondragón Duarte +2 more
doaj +1 more source
La reforma de los mecanismos de control en la Real Hacienda de Nueva España (siglos XVI-XVIII)
Anuario de Estudios Americanos, 2019 El trabajo desarrolla una faceta de las medidas jurídico-administrativas desplegadas por la Monarquía hispánica sobre la Real Hacienda de Nueva España entre los siglos XVI y XVIII, a saber: los mecanismos de control, haciendo hincapié en la conformación ...
Ernest Sánchez Santiró
doaj +1 more source