Results 61 to 70 of about 37,401 (266)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Aspectos sustanciales de la responsabilidad fiscal en Colombia

Civilizar, 2007
El presente artículo tiene como objeto evaluar los elementos sustantivos de la Responsabilidad Fiscal, la cual se fundamenta a su turno en las condiciones básicas requeridas para el ejercicio del control fiscal.
Carlos Ariel Sánchez
doaj   +1 more source

CONTROL INTERNO Y REVISORÍA FISCAL

Contaduría Universidad de Antioquia, 2016
En este artículo se enfoca la revisoría fiscal desde el punto de vista del control interno, entendiéndose por éste, el que se da la misma empresa para que los procesos y las personas conduzcan hacia el logro de los objetivos organizacionales. La revisoría fiscal requiere de una disposición activa y crítica, por ello, su labor de vigilancia agrupa un ...
openaire   +2 more sources

CONTROL FISCAL (COMPARATIVE STUDY)‎

International Journal of Humanities and Educational Research, 2022
The fiscal administration possesses a number of powers, which is known as the fiscal authority, which gives it the ability to monitor the validity of written declarations, and taxes paid by taxpayers. In order to carry out control operations, the Algerian legislator developed a set of legal and regulatory texts, to control and ...
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Responsabilidad fiscal

Revista Estudios Socio-Jurídicos, 2010
Una de las características distintivas del sistema constitucional adoptado en 1991 es el desarrollo de mecanismos de control al ejercicio de la autoridad, uno de los cuales es el control fiscal, que bajo un tratamiento normativo diferente del vigente ...
Manuel Alberto Restrepo-Medina
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Estimation of Fiscal Reaction Functions and Determinants of Fiscal Sustainability in Iran Employing Linear and Nonlinear Functions [PDF]

اقتصاد باثبات
Governments pursue macroeconomic objectives such as stabilizing the economy by employing fiscal policy tools. However, fiscal sustainability is obligatory for achieving economic stability.
Hossein Aghilifar, Khosrow Piraei, hashem zare, Mehrzad Ebrahimi   +3 more
doaj   +1 more source