Results 141 to 150 of about 773,209 (312)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Adaptive Locomotion of Planar Snake Robots: Body Shape Control and Path-Following

openSnake robots constitute a class of hyper-redundant, articulated systems inspired by their biological counterpart. Their many degrees of freedom make them challenging to control, but provide unique locomotion capabilities in irregular and challenging ...
MORSELLI, ALBERTO
core  

Continuous Damping Control for Semi-Active Suspension

, 2014
[[abstract]]This paper describes the development of a continuous damping control law for the 2-DOF model of the vehicle with a semi-active suspension. The suspension system consists of a continuously variable damper that can vary the suspension stiffness
Lin, Chih-Jer; Wu, Jian-Da; Tai, Chia-Wei; Kuo, Kun-Yin
core  

Infinite horizon and ergodic optimal quadratic control for an affine equation with stochastic coefficients

, 2009
We study stochastic optimal control problems with a quadratic cost and linear state equation that involves stochastic coefficients and control dependent noise and, moreover, is perturbed by an affine term.
F. MASIERO, GUATTERI, GIUSEPPINA
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimal Control in Coefficients for Degenerate Linear Parabolic Equations

, 2014
The aim of this work is to study the optimal control problem associated to a linear parabolic equation with homogeneous Dirichlet boundary condition. The control variable is the matrix of L1-coefficients in the main part of the parabolic operator. The
I. G. Balanenko, MANZO, Rosanna
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Non-parametric H-infinity control synthesis with suboptimal controller sets

, 2008
The effectiveness of norm-based control methodologies heavily relies on the quality of the model that describes the dynamic behavior of the plant. In practical applications, the requirement to accurately describe the system at hand often results in high ...
Steinbuch, M Maarten, Weiland, S Siep, Steinbuch, M., Angelis, GZ, Hamer, den, A.J., Hamer, AJ Arjen den, Angelis, G.Z., Cho, Hyungsuck, Weiland, S., Steinbuch, M.; id_orcid   +9 more
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Stages and main problems of the century-long control theory and system identification development. Part 5. Principles and problems in control and identification of complex systems of various nature based on cognitive maps impulse processes models

Міжнародний науково-технічний журнал "Проблеми керування та інформатики"
The article provides a review and generalization of the principles, methods and problems of designing discrete controllers for controlling complex systems of various nature, the dynamics of which are described using difference equations of cognitive ...
Віктор Демидович Романенко, Вячеслав Федорович Губарев, Юрій Леонідович Мілявський   +2 more
doaj   +1 more source