Results 91 to 100 of about 2,090,875 (313)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Adverse events following immunization surveillance on two types of enterovirus 71 vaccines: A real-world comparative study in China

Human Vaccines & Immunotherapeutics
To comprehensively assess the safety and difference of two types of EV71 vaccines: EV71-Vero, produced using Vero cells and EV71-H2, using human diploid cells.
Yiqing Zhu, Yihan Wang, Jinghui Wang, Yafei Wang, Li Sun, Shiheng Cui, Jing Li, Yu Guo   +7 more
doaj   +1 more source

Outbreak control management: Lessons from SARS-CoV-2 infections in 2020-2022 in Hong Kong, an international municipality with high-frequency travelers. [PDF]

MedComm (2020), 2022
Feng Y, Young CH, Lau SH, He ML.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Relationship between ventilator-associated pneumonia and prognosis among patients in cardiac surgical intensive care units: a retrospective analysis based on the MIMIC database

The Egyptian Journal of Bronchology
Background Ventilator-associated pneumonia (VAP) is a frequent nosocomial infection in patients undergoing cardiac surgery, contributing to prolonged hospitalization and increased healthcare burden.
Bo Song, Guanjun Jiang, Yujia Liu, Dongsheng Cheng   +3 more
doaj   +1 more source

Nitrogen and Chemical Control Management Improve Yield and Quality in High-Density Planting of Maize by Promoting Root-Bleeding Sap and Nutrient Absorption. [PDF]

Front Plant Sci, 2022
Liu X, Zhang L, Yu Y, Qian C, Li C, Wei S, Li C, Gu W.   +7 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Effect of implementing quality control management in the treatment of severely injured patients: a retrospective cohort study in a level I trauma center in China. [PDF]

BMC Emerg Med, 2022
Du Z, Wang T.
europepmc   +1 more source

How Integrating Service Production, Quality Control, Inventory Management for Small Retail Coffee Industry: A Case Study [PDF]

, 2023
Yumna Zahran Ramadhan, Warih Puspitasari, Muhardi Saputra, Muharman Lubis   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source