Results 81 to 90 of about 29,428,952 (401)

Community screening for dementia among older adults in China: a machine learning-based strategy

BMC Public Health
Background Dementia is a leading cause of disability in people older than 65 years worldwide. However, diagnosing dementia in its earliest symptomatic stages remains challenging.
Yan Zhang, Jian Xu, Chi Zhang, Xu Zhang, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yijin Zheng, Zhiguang Zhao   +8 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population

BMC Geriatrics
Objective Our study aimed to investigate the relationship between the number of teeth remaining and cognitive impairment among Chinese older adults, and to explore the role of low body weight in this association. Methods Data were drawn from 2011 to 2014
Pan Ke, Zuxun Lu, Wenqing Ni, Yan Zhang, Hongmin Zhang, Yijin Zheng, Xueli Yuan, Jian Xu, Xiaoxv Yin, Zhiguang Zhao   +9 more
doaj   +1 more source

Strategies for the control of Rhipicephalus microplus ticks in a world of conventional acaricide and macrocyclic lactone resistance [PDF]

, 2018
Infestations with the cattle tick, Rhipicephalus microplus, constitute the most important ectoparasite problem for cattle production in tropical and subtropical regions worldwide, resulting in major economic losses. The control of R.
Bhushan, Chandra, Jonsson, Nicholas N., Rodriguez-Vivas, Roger I.   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cross‐view face recognition via structured dictionary based domain shift

IET Computer Vision, 2015
View variation is a major challenge in face recognition. In this study, the authors propose a novel cross‐view face recognition method by seeking potential intermediate domains between the source and target views to model the connection of varying‐views ...
Xue Chen, Chunheng Wang, Baihua Xiao, Xinyuan Cai   +3 more
doaj   +1 more source

What is a suitable management for Typha latifolia control in wet meadows? [PDF]

, 2023
Jan Titěra, Lenka Pavlů, V. Pavlů, Petr Blažek   +3 more
openalex   +1 more source

Behavioral Factors Influencing Health Outcomes in Youth with Type 1 Diabetes [PDF]

, 2012
The Pediatric Self-Management Model provides an overview of how behavioral factors influence children’s chronic medical illnesses. This general framework is used to organize the present review of how self-management behaviors, contextual factors, and ...
Kaugars, Astrida S., Kichler, Jessica C., Moss, Ashley   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development and validation of a scale to measure hypertensive Chinese individual’s behavior toward salt reduction consumption

BMC Public Health
Objective This study aimed to develop and validate the Salt Reduction Behavior Scale (SRBS) to measure the behavior of hypertensive Chinese individuals in adhering to salt reduction practices.
Le Han, Ying Liu, Xiao Liu, Peng Xian
doaj   +1 more source