Results 1 to 10 of about 130,329 (268)

Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator function. [PDF]

PLoS Genetics, 2010
The misexpressed imprinted genes causing developmental failure of mouse parthenogenones are poorly defined. To obtain further insight, we investigated misexpressions that could cause the pronounced growth deficiency and death of fetuses with maternal ...
Li Han, Piroska E Szabó, Jeffrey R Mann
doaj   +6 more sources

Chromosome duplication causes premature aging via defects in ribosome quality control. [PDF]

PLoS Biology
Down syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span.
Leah E Escalante, James Hose, Jamie M Ahrens, Hollis Howe, Norah Paulsen, Sofia J Liss, Michael Place, Audrey P Gasch   +7 more
doaj   +3 more sources

Spatial and temporal organization of chromosome duplication and segregation in the cyanobacterium Synechococcus elongatus PCC 7942. [PDF]

PLoS ONE, 2012
The spatial and temporal control of chromosome duplication and segregation is crucial for proper cell division. While this process is well studied in eukaryotic and some prokaryotic organisms, relatively little is known about it in prokaryotic polyploids
Anna H Chen, Bruno Afonso, Pamela A Silver, David F Savage   +3 more
doaj   +5 more sources

Genetic control of mitochondrial malate dehydrogenases: evidence for duplicated chromosome segments. [PDF]

Proceedings of the National Academy of Sciences, 1977
The genetic control of the major mitochondrial isoenzymes of malate dehydrogenase (L-malate:NAD+ oxidoreductase; EC 1.1.1.37) has been investigated in Zea mays. The mitochondrial isozymes are coded at four nuclear gene loci. Two of the loci (mdh1 and mdh2) are diallelic and tightly linked.
N S, Yang, J C, Sorenson, J G, Scandalios   +2 more
openaire   +4 more sources

Control of large chromosomal duplications in Escherichia coli by the mismatch repair system. [PDF]

Genetics, 1991
Abstract Excessive recombination between repeated, interspersed, and diverged DNA sequences is a potential source of genomic instability. We have investigated the possibility that a mechanism exists to suppress genetic exchange between these quasi-homologous (homeologous) sequences.
M A, Petit, J, Dimpfl, M, Radman, H, Echols   +3 more
openaire   +3 more sources

Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls [PDF]

Human Molecular Genetics, 2011
Recurrent rearrangements of chromosome 1q21.1 that occur via non-allelic homologous recombination have been associated with variable phenotypes exhibiting incomplete penetrance, including congenital heart disease (CHD). However, the gene or genes within the ~1 Mb critical region responsible for each of the associated phenotypes remains unknown.
Soemedi R, Topf A, Wilson IJ, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Setchfield K, Bu'lock F, Thornborough C, Devreindt K, Breckpot J, Hofbeck M, Lathrop M, Rauch A, Blue G, Winlaw D, Hurles M, Santibanez-Koref M, Cordell H, Goodship J, Keavney B   +27 more
openaire   +7 more sources

Complexities of Chromosome Landing in a Highly Duplicated Genome: Toward Map-Based Cloning of a Gene Controlling Blackleg Resistance in Brassica napus [PDF]

Genetics, 2005
Abstract The LmR1 locus, which controls seedling resistance to the blackleg fungus Leptosphaeria maculans in the Brassica napus cultivar Shiralee, was positioned on linkage group N7. Fine genetic mapping in a population of 2500 backcross lines identified three molecular markers that cosegregated with LmR1. Additional linkage mapping in a
Reinhold, Mayerhofer, Kris, Wilde, Marion, Mayerhofer, Derek, Lydiate, Vipan K, Bansal, Allen G, Good, Isobel A P, Parkin   +6 more
openaire   +4 more sources

Unique signatures of natural background radiation on human Y chromosomes from Kerala, India. [PDF]

PLoS ONE, 2009
BackgroundThe most frequently observed major consequences of ionizing radiation are chromosomal lesions and cancers, although the entire genome may be affected.
Sanjay Premi, Jyoti Srivastava, Sebastian Padinjarel Chandy, Sher Ali   +3 more
doaj   +1 more source

Genome-Wide Survey and Expression Analysis of the Basic Leucine Zipper (bZIP) Gene Family in Eggplant (Solanum melongena L.)

Horticulturae, 2022
The transcription factors (TFs) family known as the basic leucine zipper (bZIP) plays a vital role in a variety of biological processes. However, there is no investigation on the bZIP family in the major vegetable crop, eggplant.
Yan Li, Guoxin Yao, Yafang Tang, Xudong Lu, Xiu Qiao, Cheng Wang   +5 more
doaj   +1 more source

The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. [PDF]

PLoS ONE, 2017
Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine.
Catherine P M Hayward, Minggao Liang, Subia Tasneem, Asim Soomro, John S Waye, Andrew D Paterson, Georges E Rivard, Michael D Wilson   +7 more
doaj   +1 more source