Results 181 to 190 of about 70,597 (264)

Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations

ChemistryOpen, EarlyView.
A systematic computational workflow integrates Protein–Ligand Affinity prediction NETwork (PLANET), a GPU‐accelerated version of AutoDock Vina (Vina‐GPU), molecular mechanics/generalized born surface area (MM/GBSA), absorption distribution metabolism excretion toxicity prediction (admetSAR 3.0), molecular dynamics (MD), and absolute binding free energy
Xi Chen, Xinle Yang, Roufen Chen, Lei Xu, Xiaowu Dong, Zhen Cai   +5 more
wiley   +1 more source

Effect of ayres sensory integration ^®-based occupational therapy intervention on sensory processing in a child with 4p trisomy and 10q monosomy: a case report. [PDF]

BMC Pediatr
Buğday T, Cemali M, Karaduman AA.
europepmc   +1 more source

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression

The Journal of Pathology, EarlyView.
Abstract Development of ipsilateral breast carcinoma following a diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not always be the case, and it is important to determine how often such recurrences represent new tumours.
Tanjina Kader, Maia Zethoven, Sakshi Mahale, Hugo Saunders, Lauren Tjoeka, Rebecca Lehmann, Madawa W Jayawardana, Jia‐Min Pang, Dorothea Lesche, Neeha Rajan, Timothy Semple, Jue Er Amanda Lee, Richard Lupat, David J Byrne, Siobhan Hughes, Hoa Nguyen, Siqi Lai, Maree Pechlivanis, Olivia Craig, Lisa Devereux, Eloise House, Sureshni I Jayasinghe, Tom L Kaufmann, Roland F Schwarz, Andrew R Green, Islam M Miligy, Margaret Cummings, Sunil Lakhani, Ian G Campbell, Emad Rakha, Stephen B Fox, G Bruce Mann, Kylie L Gorringe   +32 more
wiley   +1 more source

Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes. [PDF]

Genome Med
Wang Y, Sams EI, Slaugh R, Crocker S, Hurtado EC, Tracy S, Hou YC, Markovic C, Valle K, Tate V, Belhassan K, Appelbaum E, Akinwe T, Starosta RT, Cao Y, Neilson A, Liu Y, Jensen N, Ghasemi R, Lindsay T, Manuel J, Couteranis S, Kremitzki M, Ustanik J, Antonacci T, Ng JK, Emory A, Metz L, DeLuca T, Lyons KN, Sinnwell T, Thomeczek B, Wang K, Sisneros N, Muraleedharan M, Kethireddy A, Corbo M, Gowda H, King KA, Gurnett CA, Dutcher SK, Gooch C, Li YE, Mitchell MW, Peterson KA, Horani A, Rosenfeld JA, Bi W, Stankiewicz P, Chao HT, Posey JE, Grochowski CM, Dardas Z, Puffenberger EG, Pearson CE, Kooy F, Annear D, Innes AM, Heinz M, Head R, Fulton R, Toutain S, 9P-ARCH, Antonacci-Fulton L, Cui X, Mitra RD, Cole FS, Neidich J, Dickson PI, Milbrandt J, Turner TN.   +70 more
europepmc   +1 more source

Segmental duplications mediate novel, clinically relevant chromosome rearrangements.

Human Molecular Genetics, 2009
M. Katharine, Rudd Ã, J. Keene, B. Bunke, E. B. Kaminsky, M. Adam, J. Mulle, D. Ledbetter, C. Martin   +8 more
semanticscholar   +1 more source

Whole Genome Sequencing in Prenatal Diagnostics: The Danish Approach to Guideline Formation and Implementation Within Public Healthcare

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the implementation of whole genome sequencing (WGS) in prenatal diagnostics and outline the national guideline system facilitating this. Methods Clinical guidelines for WGS in prenatal diagnostics were developed and implemented by the Danish Fetal Medicine Society.
Ida Vogel, Lotte Andreasen, Marie Balslev‐Harder, Naja Becher, Anja Ernst, Kasper Gadsbøll, Tina Duelund Hjortshøj, Marie Skov Hvidbjerg, Martin Larsen, Stina Lou, Ida Charlotte Bay Lund, Lars Henning Pedersen, Laura Kirstine Sønderberg Roos, Lene Sperling, Lone Sunde, Pernille Mathiesen Tørring, Cathrine Vedel, Olav Bjørn Petersen   +17 more
wiley   +1 more source

Genome-wide identification and characterization of the Brassinazole-resistant gene family and associated responses to osmotic stress in <i>Avena sativa</i>. [PDF]

Front Plant Sci
Xu S, Wei Z, Ma M, Zhang L, Liu Z, Liu L.   +5 more
europepmc   +1 more source

A Prospective Evaluation of the Diagnostic Utility for Low‐Coverage Genome Sequencing in Prenatal Samples: A Comparison With Chromosomal Microarray Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective The present study aimed to evaluate the efficacy of LC‐GS in detecting clinically relevant chromosomal abnormalities in comparison with conventional CMA within a prenatal context. Methods We conducted a prospective study involving 200 amniotic fluid samples.
Yan Yin, Yuxia He, Chun Chen, Yanyan He, Jin Wang, Shengfang Qin, Hongna Wang, Kun Ma, Dahui Hu, Rui Xiao, Gang Wang, Xueyan Wang   +11 more
wiley   +1 more source

Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos. [PDF]

Transgenic Res
Parkinson JE, Baldwin GE, Papotto PH, Humphreys NE, Day AJ, Adamson AD, Allen JE, Sutherland TE.   +7 more
europepmc   +1 more source

Prenatal Metabolomics Analysis and Fetal Congenital Anomalies and Genetic Conditions: A Review of Current Literature

Prenatal Diagnosis, EarlyView.
ABSTRACT Fetal congenital anomalies and genetic disorders complicate 3%–5% of pregnancies and can have a significant impact on pregnancy outcomes. Precise and individualized prenatal diagnosis is crucial for effective counseling and management.
Sarah Araji, Onur Turkoglu, Mohamad Ali Maktabi, Tracy Ashby, Ignatia B. Van den Veyver   +4 more
wiley   +1 more source