Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Learning a musical instrument: the influence of interpersonal interaction on outcomes for school-aged pupils [PDF]
Researchers in recent years have increasingly placed an emphasis on seeking pupils' perceptions of educational settings. Alongside this shift towards attaching value to the pupil viewpoint has been a growing interest concerning how interpersonal ...
Creech, Andrea, Hallam, Susan
core +2 more sources
Understanding the differential benefits of training for the unemployed [PDF]
[Abstract]: This study examined the connection between background variables (such as length of unemployment and number of previous training courses), contextual variables (perceptions of training climate), dispositional variables (positive affect and ...
Creed, Peter A., Machin, M. Anthony
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Staff perceptions on pigeon control strategies on the University of South Africa’s Muckleneuk campus
Pigeons are often considered a nuisance in urban environments, leading to the attempted control or eradication of their populations. This study explored the perceptions of 246 staff members employed on the University of South Africa’s Muckleneuk campus ...
Emma Harris +2 more
doaj +1 more source
Perceptions about Authentic Leadership Development: South African Occupational Therapy Students\u27 Camp Experience [PDF]
Background. Twenty-three years into democracy, concern is deepening regarding the slow progress of Occupational Therapy (OT) in South Africa, especially with regard to diversity and inclusion within OT. Methods.
Hendricks, Fatima, Toth-Cohen, Susan
core +1 more source
A thematic synthesis of the experiences of adults living with hemodialysis [PDF]
Background and objectives In-center dialysis patients spend significant amounts of time on the dialysis unit; additionally managing ESKD affects many aspects of life outside the dialysis unit.
Jones, Colin +2 more
core +1 more source
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
Migrant Farmworkers\u27 Perceptions of Pesticide Risk Exposure in Adams County, Pennsylvania: A Cultural Risk Assessment [PDF]
Agricultural exceptionalism, a system in which regular labor laws and standards do not apply to farm labor, makes migrant farmworkers particularly vulnerable populations—economically, socially, and in terms of environmental health.
Edelson, Micaela S. G. +2 more
core +2 more sources
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source

