Results 261 to 270 of about 19,092,455 (347)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Ultrasound-Guided Superficial Versus Deep Continuous Serratus Anterior Plane Block in Patients Undergoing Thoracotomy for Lung Surgery: A Randomized Controlled Trial. [PDF]

Ann Card Anaesth
Raghupathy R, Negi SL, Biswas I, Singh H, Mandal B, Gourav KP, Sharma A.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Generating vectorial optical fields via surface-wave-excited complex-amplitude metasurfaces. [PDF]

Light Sci Appl
Jin X, He Y, Li J, Nie X, Du S, Song Y, Luo H, Liu M, Ma S, He Q, Zhou L, Wang Z, Sun S.   +12 more
europepmc   +1 more source

Erector spinae plane block for opioid sparing in children undergoing laparoscopic appendectomy: a randomized controlled trial. [PDF]

Front Pediatr
Yang MW, Cai YZ, Zhang LL, Wang J, Tang R, Sun YY.   +5 more
europepmc   +1 more source

Metacrystals: inversely-designed 3D-printed intelligent panels for 6G communications. [PDF]

Nat Commun
Asgari MM, Catrysse PB, Yuan SSA, Wang H, Fan S, Asadchy V.   +5 more
europepmc   +1 more source

Clinical, radiographic, and histological evaluation of autogenous demineralized dentin matrix versus xenograft in alveolar ridge preservation: a randomized controlled trial. [PDF]

Int J Implant Dent
Xu Y, Zhang H.
europepmc   +1 more source

Transversus Abdominis Plane Block in the Emergency Department for Paracentesis: A Case Report. [PDF]

Cureus
Patel M, Husain A, Gappy R, Park A, Clark CR.   +4 more
europepmc   +1 more source