Results 151 to 160 of about 26,864,091 (348)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

STATISTICAL PROCEDURES IN THE QUALITY CONTROL OF THE GEARS

open access: yesВестник Донского государственного технического университета, 2018
The production technology of the quality control, it’s strategy and planning in the process planning with the ability of aid with the computer is the important component of the improvement of the quality  stability of the production according to the set ...
K. WECZEROWSKI, JA. UNIEJEWSKI
doaj  

Adaptive p-value weighting with power optimality

open access: yes, 2019
Weighting the p-values is a well-established strategy that improves the power of multiple testing procedures while dealing with heterogeneous data. However, how to achieve this task in an optimal way is rarely considered in the literature.
Durand, Guillermo
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Editorial: Demonstrating quality control (QC) procedures in fMRI

open access: yesFrontiers in Neuroscience, 2023
Paul A. Taylor   +5 more
doaj   +1 more source

STATISTICAL PROCEDURES IN THE QUALITY CONTROL OF THE GEARS

open access: yesAdvanced Engineering Research, 2006
The production technology of the quality control, it’s strategy and planning in the process planning with the ability of aid with the computer is the important component of the improvement of the quality  stability of the production according to the set ...
K. WECZEROWSKI, JA. UNIEJEWSKI
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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