The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Behavioral Inhibition Places Preschoolers at Risk for Reduced Social Competence, but Only in the Context of Other Temperamental Traits. [PDF]
Children (Basel)Fleece H, Teglasi H.
europepmc +1 more source
Automatic Justice? Technology, Crime and Social Control [PDF]
, 2015 Amber Marks, Ben Bowling, Colman Keenan
openalex
The Culture of Fear and Control in Costa Rica (II): The Talk of Crime and Social Changes
, 2009 Sebastián Huhn
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
IntelliProfiler: a research workflow for analyzing multiple animals with a high-resolution home-cage RFID system. [PDF]
Lab Anim (NY)Ochi S, Inada H, Osumi N.
europepmc +1 more source
Cooperation in social dilemmas: The necessity of seeing self-control conflict
, 2012 Peter Martinsson +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source