Results 151 to 160 of about 5,820,048 (335)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

The Effect of Friction in the Automatic Control System on Controlling Action

, 1953
Toshio Nishihara, Yoshikazu SAWARAGI, Taizo SAWAMURA   +2 more
openalex   +2 more sources

Closure to “Discussions of ‘Nondimensional Study of Proportional-Plus-Reset Control of a Single-Capacity System’” (1951, Trans. ASME, 73, pp. 516–517) [PDF]

, 1951
J. A. Hrones, J. B. Reswick
openalex   +1 more source

MEGARA control system [PDF]

, 2013
MEGARA (Multi-Espectrografo en GTC de Alta Resolucion para Astronomia) is an optical Integral-Field Unit (IFU) and Multi-Object Spectrograph (MOS) designed for the GTC 10.4 m telescope in La Palma. The MEGARA Control System will provide the capabilities to move the different mechanisms of the instrument, to readout the data from the detector controller
Castillo Morales, María África, Eliche Moral, María del Carmen, Pascual Ramírez, Sergio, Marino, Raffaella Anna, Villar, V., Cardiel López, Nicolás, Morales, I., González, E., Cedazo, R., Serena, F., Gallego Maestro, Jesús, Carrasco, E., Vílchez, J. M., Sánchez, F. M., Gil De Paz, Armando, García Vargas, M. L.   +15 more
openaire   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Recent Problems in Discontinuous Control Systems

, 1953
Keisuke IZAWA
openalex   +2 more sources

Closure to “Discussions of ‘On the Automatic Control of Generalized Passive Systems’” (1952, Trans. ASME, 74, pp. 183–185) [PDF]

, 1952
Kun Li Chien, J. A. Hrones, J. B. Reswick   +2 more
openalex   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Electrical Systems Regulators and their Applications in Automatic Control

, 1953
Chihiro Hayashi, Hiroshi Nishihara, Michiyoshi Kuwahara   +2 more
openalex   +2 more sources

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source