Results 71 to 80 of about 5,820,048 (335)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Discrete Control Systems

open access: yes, 2009
Discrete control systems, as considered here, refer to the control theory of discrete-time Lagrangian or Hamiltonian systems. These discrete-time models are based on a discrete variational principle, and are part of the broader field of geometric integration.
Lee, Taeyoung   +2 more
openaire   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

On the application of the calculus of positively constructed formulas for the study of controlled discrete-event systems

open access: yesМоделирование и анализ информационных систем
The article is devoted to the development of an approach to solving the main problems of the theory of supervisory control of logical discrete-event systems (DES), based on their representation in the form of positively constructed formulas (PCF).
Artem Davydov   +2 more
doaj   +1 more source

Intentional Recreational Abuse of Quetiapine Compared to Other Second-generation Antipsychotics

open access: yesWestern Journal of Emergency Medicine, 2017
Introduction: Case reports and poison center data have demonstrated that the second-generation antipsychotic quetiapine is being obtained and used for recreational abuse.
Lauren Klein, Stacey Bangh, Jon B. Cole
doaj   +1 more source

Control Sets for Affine Systems, Spectral Properties and Projective Spaces [PDF]

open access: yesSIAM J. Control Optim. Vol. 61(2023), pp. 647-673, 2022
For affine control systems with bounded control range the control sets, i.e., the maximal subsets of complete approximate controllability, are studied using spectral properties. For hyperbolic systems there is a unique control set with nonvoid interior and it is bounded. For nonhyperbolic systems, these control sets are unbounded.
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Linear time logic control of linear systems with disturbances [PDF]

open access: yesarXiv, 2012
The formal analysis and design of control systems is one of recent trends in control theory. In this area, in order to reduce the complexity and scale of control systems, finite abstractions of control systems are introduced and explored. In non-disturbance case, the controller of control systems is often generated from the controller of finite ...
arxiv  

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

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