Results 161 to 170 of about 28,889,117 (325)

Oromotor Nonverbal Performance and Speech Motor Control: Theory and Review of Empirical Evidence. [PDF]

Brain Sci, 2023
Weismer G.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Optimal control theory as a method for designing multidrug adaptive therapy regimens. [PDF]

NPJ Syst Biol Appl
Widdershins A, Hansen E, Read A, Hohl R.
europepmc   +1 more source

Pandemic control - do's and don'ts from a control theory perspective. [PDF]

World J Methodol, 2022
Tomov L, Miteva D, Sekulovski M, Batselova H, Velikova T.   +4 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Inferring intrinsic neural timescales using optimal control theory. [PDF]

Nat Commun
Kim JZ, Betzel RF, Beyh A, Howell A, Kuceyeski A, Larsen B, Seguin C, Zhang XH, Holmes A, Parkes L.   +9 more
europepmc   +1 more source

Analysis of fractional order model on higher institution students' anxiety towards mathematics with optimal control theory. [PDF]

Sci Rep, 2023
Teklu SW.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

CTAS: a network control theory-based approach to identify key regulatory TFs of AS events during epithelial-mesenchymal transition. [PDF]

Brief Bioinform
Gan Y, He Y, Zhao P, Ching WK, Qiu Y.
europepmc   +1 more source

Identifying preeclampsia-associated genes using a control theory method. [PDF]

Brief Funct Genomics, 2022
Li X, Liu L, Whitehead C, Li J, Thierry B, Le TD, Winter M.   +6 more
europepmc   +1 more source