Results 161 to 170 of about 59,747,375 (260)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Autoriza a instituição do Programa de Gestão e Desempenho na DGCI

Autoriza a instituição do Programa de Gestão e Desempenho – PGD no/a Diretoria de Governança, Controles Internos e ...
Diretoria de Governança, Controles Internos e Integridade
core  

Screening PTSD in clinical populations within East Africa: results from the first follow-up study of NeuroGAP-psychosis. [PDF]

Eur J Psychotraumatol
Jha SC, Stroud RE, Dice ALE, Kyebuzibwa J, Gichuru S, Ochieng F, Sharma M, Mountcastle H, Marshall L, Ongeri L, Korte KJ, Koenen KC, Atwoli L, Akena D.   +13 more
europepmc   +1 more source

[Technological and productive trajectory of the human vaccine industry in Mexico: post-Covid-19 perspectives]. [PDF]

Rev Salud Publica (Bogota), 2023
Pérez-Hernández MDPM, Castillo-Chávez LM.   +1 more
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Melhorando a apresentação de informações sobre equidade em saúde em pesquisas observacionais (STROBE-Equity): lista de verificação estendida e sua elaboração. [PDF]

Rev Panam Salud Publica
Dewidar O, Shamseer L, Melendez-Torres GJ, Akl EA, Ramke J, Wang X, Oloyede O, Young T, Nicholls SG, Marshall Z, Kennedy M, Hardy BJ, Rizvi A, Ghogomu E, Rader T, Waddington HS, Shea B, Nguilefem MN, Ellingwood H, Wolfenden L, Tufte J, Horsley T, Pottie K, Cuervo LG, Juando-Prats C, Feng C, Sharp MK, Little J, Owusu-Addo E, Francis D, Kredo T, Mahande MJ, Chamberlain C, Pantoja T, von Elm E, Bhutta ZA, Tugwell P, Wiysonge CS, Funnell S, Jull J, Mbuagbaw L, Welch V.   +41 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Block 14 of Subdivision no. 10, Stromlo District [cartographic material] /

, 1926
Cadastral map of Stromlo Pine Forest region, Australian Capital Territory, showing blocks of land with boundaries, waterways and roads.; In upper middle margin: Federal Capital Commission.; In lower right margin: Sheet 10, Field books F.4255, F.4330, A ...
Australia. Federal Capital Commission.
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Tuberculosis and social aspects in a Brazilian state of high vulnerability: a systematic review. [PDF]

Rev Bras Enferm
Montelo ES, Oliveira AS, Rodrigues ZMR, Sardinha AHL.   +3 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source