Results 31 to 40 of about 217,968 (284)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Ineffective controls on capital inflows under sophisticated financial markets: Brazil in the nineties [PDF]

We analyze the Brazilian experience in the 1990s to access the effectiveness of controls on capital inflows in restricting financial inflows and changing their composition towards long term flows.
Bernando S. de M. Carvalho, Márcio Gomes Pinto Garcia   +1 more
core   +6 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Faixa de fronteira - Capital estrangeiro - Controle acionário

Revista de Direito Administrativo, 1981
- A exigência de maioria de capital nacional em empresa que se dedicar a atividade em área de faixa de fronteira deve entender-se como defesa do controle brasileiro, não sendo vedada a participação de sócio minoritário estrangeiro.
openaire   +1 more source

POLÍTICA DE TIERRAS, CAPITAL AGRARIO Y CONTROL SOCIAL.

, 2018
Fil: Hocsman, Luis Daniel. Universidad Nacional de Córdoba. Centro de Estudios Avanzados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba.
Hocsman, Luis Daniel, Romano, Mariana
openaire   +2 more sources

PROGRAMA DE CONTROLE DA HANSENÍASE EM CAPITAL HIPERENDÊMICA: UMA AVALIAÇÃO OPERACIONAL

Revista Baiana de Enfermagem‏, 2018
<p>Objetivo: avaliar o Programa de Controle da Hanseníase em capital hiperendêmica no Brasil. Método: pesquisa de<br />avaliação, realizada em todas as instituições de saúde que operacionalizavam o programa de controle da hanseníase<br />no município de São Luís, Maranhão, Brasil, abrangendo todos os casos novos e contatos de casos de
Yara Naya Lopes de Andrade Goiabeira, Isaura Letícia Tavares Palmeira Rolim, Dorlene Maria Cardoso De Aquino, Leonardo Hunaldo Dos Santos, Alice Bianca Santana Lima, Vanessa Moreira da Silva Soeiro   +5 more
openaire   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sociedade de economia mista - Capital estrangeiro - Controle

Revista de Direito Administrativo, 1980
Tribunal de Contas da ...
openaire   +1 more source

Capital flows and financial crises: a comparative analysis of East Asia (1997-1998) and Argentina (2001-2002) [PDF]

, 2004
El texto sugiere, en primer lugar, que los mecanismos de las crisis financieras en las economías emergentes pueden entenderse con un sencillo marco teórico. En segundo término, repasa brevemente las crisis asiáticas de 1997-98.
Bustelo Gómez, Pablo
core   +1 more source