Results 91 to 100 of about 21,912,576 (328)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Controlling fast transport of cold trapped ions

, 2012
We realize fast transport of ions in a segmented micro-structured Paul trap. The ion is shuttled over a distance of more than 10^4 times its groundstate wavefunction size during only 5 motional cycles of the trap (280 micro meter in 3.6 micro seconds ...
A. Steane, A. Walther, D. Hucul, F. Schmidt-Kaler, F. Ziesel, K. Ott, K. Singer, M. Hettrich, M. Rowe, R. Bowler, S. T. Dawkins, T. Ruster, U. Poschinger   +12 more
core   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

The Relation between CSR and Innovation. Model Approach

Journal of Entrepreneurship, Management and Innovation, 2016
The paper attempts to fulfil the research gap concerning the mutual relation between company innovation and its corporate social responsibility practices, by determining the conditions in which the innovation/CSR relation appears and develops.
Dawid Szutowski, Piotr Ratajczak
doaj   +1 more source

Controlling Risk of Web Question Answering

, 2019
Web question answering (QA) has become an indispensable component in modern search systems, which can significantly improve users' search experience by providing a direct answer to users' information need.
Devlin Jacob, Dunn Matthew, Ferrucci David, Gal Yarin, Geifman Yonatan, Guo Chuan, Lai Guokun, Levy Omer, Malinin Andrey, Nguyen Tri, Richardson Matthew, Vinyals Oriol, Voorhees Ellen M., Wang Shuohang   +13 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Staphylococcus aureus-antagonizing human nasal commensal Staphylococcus lugdunensis depends on siderophore piracy

Microbiome
Background Bacterial pathogens such as Staphylococcus aureus colonize body surfaces of part of the human population, which represents a critical risk factor for skin disorders and invasive infections.
Ralf Rosenstein, Benjamin O. Torres Salazar, Claudia Sauer, Simon Heilbronner, Bernhard Krismer, Andreas Peschel   +5 more
doaj   +1 more source

The impact of changes in medical school admission procedures on study success: A comparative analysis at Hannover Medical School

GMS Journal for Medical Education
Background: In the academic year 2020/21, alterations were introduced in the admission procedures for medical studies, particularly within the selection quota (AdH). These changes reduced the significance of school-leaving grades (the Abitur) in favor of
Tsikas, Stefanos A., Fischer, Volkhard
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source