Results 111 to 120 of about 4,891,217 (276)

Evaluation of Investment Projects in Undeveloped Markets [PDF]

Problemi Ekonomiki, 2018
Using the example of a diversified industrial enterprise, there developed an approach to evaluating the prospects of the implementation of an innovation and investment project on manufacturing a product under conditions of an undeveloped sales market as ...
Usherenko Svitlana V., Kharchenko Yevhinii Yu.   +1 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The scientific and technical problems and solutions on shallow ground-source heat pump system

矿业科学学报, 2017
This paper discusses the concept and principle of shallow ground-source heat pump system(SGHPS) and studies the purpose and significance of its development.We analyze the key scientific and technical problems on SGHPS, including pump injection problem ...
Xu Shengheng, Zhou Tao, Sun Haizhou, Zeng Yifan, Liu Shouqiang, Wang Xiaolong, Wu Qiang   +6 more
doaj  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

A Bi-Objective Optimal Scheduling Method for the Charging and Discharging of EVs Considering the Uncertainty of Wind and Photovoltaic Output in the Context of Time-of-Use Electricity Price

World Electric Vehicle Journal
With the increasing share of renewable energy generation and the integration of large-scale electric vehicles (EVs) into the grid, the reasonable charging and discharging scheduling of electric vehicles is essential for the stable operation of power grid.
Xinfu Pang, Wen Jia, Haibo Li, Qingzhong Gao, Wei Liu   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Strength and microstructural properties of silt soil cured by lime-activated fly ash-GGBS under different curing temperatures

Scientific Reports
To reveal the mechanism of the influence of the curing temperature on the strength of lime activated fly ash-GGBS cured silt soil, the curing of dredged silt was carried out by using fly ash and GGBS as the curing agent and lime as the activator ...
Shunmei Gong, Songbao Feng, Shiquan Wang, Lemei Yu, Yuanyuan Chen, Qiang Xu   +5 more
doaj   +1 more source