Results 121 to 130 of about 21,912,576 (328)

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

open access: yesmBio
The species- and clone-specific susceptibility of Staphylococcus cells for bacteriophages is governed by the structures and glycosylation patterns of wall teichoic acid (WTA) glycopolymers.
Christian Beck   +12 more
doaj   +1 more source

Molecular cloning and characterization of a grapevine (Vitis vinifera L.) serotonin N-acetyltransferase (VvSNAT2) gene involved in plant defense

open access: yesBMC Genomics, 2019
Background Melatonin is a ubiquitous molecule and exists across kingdoms. Studies on melatonin in plants have mainly focused on its physiological influence on growth and development, and on its biosynthesis. A number of studies have been conducted on the
Yihe Yu   +6 more
doaj   +1 more source

WHO CONTROLS THE FAT CONTROLLER? [PDF]

open access: yesThe Denning Law Journal, 2012
Sir Topham Hatt, known to Thomas and all the other engines on the Isle of Sodor as the ‘Fat Controller’, started his career as a humble railway engineer. Yet he rose to become the Chairman and Chief Executive of the Railway Board. Sir Topham, of course, inhabited a simpler world than ours.
openaire   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

The scientific and technical problems and solutions on shallow ground-source heat pump system

open access: yes矿业科学学报, 2017
This paper discusses the concept and principle of shallow ground-source heat pump system(SGHPS) and studies the purpose and significance of its development.We analyze the key scientific and technical problems on SGHPS, including pump injection problem ...
Xu Shengheng   +6 more
doaj  

The GIBACHT fellowship: a multilateral initiative for strengthening capacity in biosafety and biosecurity towards pandemic preparedness

open access: yesFrontiers in Public Health
The German Biosecurity Programme was launched in 2013 with the aim to support partner countries overcome biological threats including natural outbreaks or the intentional misuse of highly pathogenic agents. As part of this programme, this paper describes
Eva Mertens   +18 more
doaj   +1 more source

Evaluation of Investment Projects in Undeveloped Markets [PDF]

open access: yesProblemi Ekonomiki, 2018
Using the example of a diversified industrial enterprise, there developed an approach to evaluating the prospects of the implementation of an innovation and investment project on manufacturing a product under conditions of an undeveloped sales market as ...
Usherenko Svitlana V.   +1 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

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