Results 131 to 140 of about 75,729 (192)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Obstetric Population: A Narrative Review. [PDF]

J Pain Res
Hao K, Jiang W.
europepmc   +1 more source

Monitoring Antiseizure Medication Change Using Ultra Long‐Term Electroencephalogram: A Multicenter Study

Annals of Neurology, EarlyView.
Objective Medication dose adjustments are common in treatment‐resistant epilepsy, but lack robust evidence, and patient‐reported seizure diaries have known limitations. We assessed whether ultra long‐term subcutaneous electroencephalogram (sqEEG) improves detection of seizure frequency changes after antiseizure medication adjustments.
Pedro F. Viana, Matthew McWilliam, Johannes Koren, Christina Duarte, Tamara Lisy, Christoph Baumgartner, Karl Rössler, Matthias Tomschik, Adriana Celdrán de Castro, Rodrigo Rocamora, Laura Vilella, Guido Rubboli, Sigge Weisdorf, Cecilia Friedrichs‐Maeder, Troels W. Kjaer, Sanchita Bhatia, Dympna McAleer, Khalid Hamandi, Deborah Spencer, Rajiv Mohanraj, Mark P. Richardson   +20 more
wiley   +1 more source

Health information dynamics and audience responses to avian influenza on YouTube: Implications for digital public health communication. [PDF]

PNAS Nexus
Vors L, Farouk I, Delon P, Raboisson D, Boucher JC, Lhermie G.   +5 more
europepmc   +1 more source

Reconceptualizing peptic ulcers as a psychosomatic disorder: a new etiological theory resolving a long-standing controversy surrounding <i>Helicobacter pylori</i>. [PDF]

Front Psychiatry
Dong SXM.
europepmc   +1 more source

[Progress and controversies surrounding disease-modifying treatments for Alzheimer's disease]. [PDF]

Aten Primaria
Gonzalez Moneo MJ.
europepmc   +1 more source

The "Three-Tier Regulatory Network" of Orthokeratology in Myopia Control: Evidence Weight of Underlying Mechanisms, Controversies, and New Perspectives for Clinical Translation--A Review. [PDF]

Clin Ophthalmol
Han L, He S, Dong S, Lu Y, Zhang M.
europepmc   +1 more source

Rethinking the electrographical boundaries of status epilepticus: controversies and paradoxes of the ictal-interictal continuum. [PDF]

Front Neurol
Bosque-Varela P, Jannone-Pedro N, Machegger L, Trinka E, Tsalouchidou PE.   +4 more
europepmc   +1 more source

Mechanistic Diversity in Photoexcited Radical Redox Chemistry: A Critical Evaluation

Angewandte Chemie International Edition, EarlyView.
Many high‐profile examples of photoredox catalysis are proposed to proceed via excitation of an open‐shell intermediate form of the catalyst. However, there is much debate over whether such mechanisms are realistic and, if so, exactly how they can occur.
Samuel J. Horsewill, Ryan Phelps, Joshua P. Barham, Daniel J. Scott   +3 more
wiley   +1 more source

Controversies and inequities [PDF]

Journal of Primary Health Care, 2014
Goodyear-Smith F
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