Hijackers and Hostages in Non-binding Linked-Issues Referenda: Analysis and an Application [PDF]
Non-binding referenda ('petitions') are an instrument of direct democracy that allows citizens to signal preferences to politicians outside the electoral cycle.
Goeschl, Timo
core
RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis
Advanced Science, EarlyView.Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang +12 more
wiley +1 more source
Physics training teachers: physics teaching, STS approach and controversial issues [PDF]
Investigações em Ensino de Ciências, 2009 We try in this paper to identify some difficulties that trainee Physic teachers had when dealing with controversial issues in their science teaching and their conceptions about Physics teaching.
Luciano Fernandes Silva +1 more
doaj
[Unification of pathomorphological examination of patients with neuroendocrine tumors of the pituitary gland. Controversial issues of the new classification]. [PDF]
Probl Endokrinol (Mosk), 2023 Pronin VS +5 more
europepmc +1 more source
Should the law allow sentiment to triumph over science? The retention of body parts [PDF]
, 2002 The use of human body material including tissue and organs has been controversial for many centuries. Concerns arose in the eighteenth century about practices used to obtain corpses for dissection.
Thomas, C. M.
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Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Key and controversial issues of economy decarbonization
Вестник университетаThe main issues causing scientific disputes and public discussions about the directions, methods, and speed of the Paris Climate Agreement implementation have been considered and briefly analyzed.
O. M. Makhalina, V. N. Makhalin
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Lead-Free BiFeO3-Based Piezoelectrics: A Review of Controversial Issues and Current Research State. [PDF]
Materials (Basel), 2022 Kim S, Nam H, Calisir I.
europepmc +1 more source
Advanced Science, EarlyView.Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu +12 more
wiley +1 more source