Results 41 to 50 of about 528,405 (282)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Le bruit des controverses vidéoludiques : entre infobésité et mobilisation politique en réseaux
Sciences du Jeu, 2022 Since their creation, video games seem to cause multiple controversies. In the French-speaking world, researches have mostly focused on controversies understood as specific topics.
Michael Perret, Esteban Giner
doaj +1 more source
The anti-Bayesian moment and its passing [PDF]
, 2012 The present article is the reply to the discussion of our earlier "Not only defended but also applied" (arXiv:1006.5366, to appear in The American Statistician) that arose from our memory of a particularly intemperate anti-Bayesian statement in Feller's ...
Gelman, Andrew, Robert, Christian P.
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Debating Democracy: Concepts, Histories, and Controversies
Politics and GovernanceWithin academia as much as in political practice, democracy remains a contested concept. This issue focuses on the practices of the contestation of the concept of democracy—the debates, controversies, and contestations of democracy in theory, practice ...
Claudia Wiesner, Kari Palonen
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Administrative SciencesThe increasing integration of Environmental, Social, and Governance (ESG) practices into corporate strategy has raised important questions about their financial implications.
Chrysoula Matsali +3 more
doaj +1 more source
Dialogical structures in 17th century controversies [PDF]
, 2006 This article is a contribution to historical dialogue analysis, a field of research which has gained momentum in recent years (Fritz 1995, 1997, Gloning 1999, and other articles in Jucker/Fritz/Lebsanft 1999).
Fritz, Gerd
core
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source