Results 251 to 260 of about 531,785 (337)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The complete mitochondrial genomes of <i>Litophyton</i> sp. and <i>Stereonephthya</i> sp., members of family Nephtheidae (Cnidaria: Anthozoa: Octocorallia). [PDF]

Mitochondrial DNA B Resour
Yoshioka Y, Kanai M, Koido T, Satoh N, Nagata T.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Addressing cultural and knowledge barriers to enable preclinical sex inclusive research. [PDF]

Elife
Gaskill BN, Phillips B, Ho J, Rafferty H, Olajide Onada O, Rooney A, Ahluwalia A, Karp NA.   +7 more
europepmc   +1 more source

Accessing Children’s Right to Play in Türkiye within the Fundamental Principles of the United Nations Convention on Children’s Rights

Burçak Bal Yalçın
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Legacy and impact of the 1925 Geneva Protocol: one hundred years of treaties and debates on chemical and biological weapons. [PDF]

Front Microbiol
Grunden WE, Tuovinen OH.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Editorial Statement: <i>Forensic parasitology: a new frontier in criminalistics</i>. [PDF]

Forensic Sci Res
europepmc   +1 more source

Closing Editorial: Mercury Cycling and Health Effects. [PDF]

Toxics
Bernardi JVE, Bastos WR, de Souza JR, Sousa Passos CJ.   +3 more
europepmc   +1 more source