Results 31 to 40 of about 522,574 (291)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Mitigating matrix effects for LC-MS/MS quantification of nitrosamine impurities in rifampin and rifapentine

Journal of Pharmaceutical and Biomedical Analysis Open
Since the discovery of potentially mutagenic nitrosamine impurities in pharmaceuticals in 2018, liquid chromatography-mass spectrometry (LC-MS) methods have been widely applied for the trace level quantification of nitrosamines.
Qiyao Li, Qun Xu, Nadine Lo, Allan T. Leeks, Jr., Mark Han, Marcela Nefliu, John T. Simpson, Jennifer L. Belsky   +7 more
doaj   +1 more source

Impact of Service Quality of House Wedding Events on the Service Value and Satisfaction

SHS Web of Conferences, 2014
With the current popularity of the newly emerged house wedding events (HWE), this study aims to investigate the impact of service quality of house wedding events on service value and satisfaction of customers.
Kim Soungyeon, Lee Mihye
doaj   +1 more source

Cost benefit of investment on quality in pharmaceutical manufacturing: WHO GMP pre- and post-certification of a Nigerian pharmaceutical manufacturer

BMC Health Services Research, 2017
Background Pharmaceutical companies in Africa need to invest in both facilities and quality management systems to achieve good manufacturing practice (GMP) compliance.
Chimezie Anyakora, Obinna Ekwunife, Faith Alozie, Mopa Esuga, Jonathan Ukwuru, Steve Onya, Jude Nwokike   +6 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Wilms tumour: Long-term survival of patients treated at Mbingo Baptist Hospital in Cameroon between 2007 and 2012

South African Journal of Oncology, 2019
Background: The survival rate of Wilms tumour (WT) in low-income sub-Saharan countries in Africa is below 50%. Thirty-five consecutive children diagnosed with WT between 2007 and 2012 at Mbingo Baptist Hospital, Cameroon, were observed in this study and ...
Peter B. Hesseling, Richard Bardin, James A. Brown, Comfort Kimbi, Heather Draper, Peter McCormick, Francine Kouya   +6 more
doaj   +1 more source

FORMAL AND LEGAL BASIS FOR THE INSTITUTIONALISATION OF INTERNATIONAL COMMERCIAL ARBITRATION: 100 YEARS OF EXPERIENCE

Baltic Journal of Economic Studies, 2023
The article reveals the formal-legal basis for the institutionalisation of international commercial arbitration. It is found that states are still far from a unified understanding of the basic scope of human rights, but they have a clear common vision of
Oleksii Makarenkov, Lurdes Varregoso Mesquita   +1 more
doaj   +1 more source

International Convention on the Elimination of All Forms of Racial Discrimination, 1965

International Human Rights Law Documents, 2018
The Chairperson welcomed all participants to the thematic discussion on racist hate speech, the aim of which was to stimulate reflection and enhance understanding of the causes and consequences of racist hate speech and how the resources of the ...

semanticscholar   +1 more source