Results 61 to 70 of about 522,574 (291)

Cooperatives on Focus: The Case of Client Relation Practices in the Province of Cavite

open access: yesJournal of Education, Management and Development Studies
Cooperatives are valuable economic stimuli in the Philippines, contributing to fast economic growth since cooperatives can inject funds and resources that may use in the market.
Xavier Lawrence Mendoza   +3 more
doaj   +1 more source

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

open access: yesFEBS Letters, EarlyView.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk   +3 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Identification of Neutralization of the CMR Documents in European Union Conditions

open access: yesCommunications, 2020
Year 1956 was an important year for international road and freight transport. By this year Convention on the Contract for the International Carriage of Goods by Road (CMR) was made.
Milos Poliak   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Chorusing or questioning: Using EQs and KWLs in the science classroom in Anglophone Cameroon

open access: yesAfrican Journal of Teacher Education and Development
Background: Teacher-led recitation, choral responses, and rote learning are common in primary Science classrooms across sub-Saharan Africa. This study examines the impact of teacher training that implemented two pedagogical strategies, Essential ...
Susan Lowes   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Nicolas Brisset, Performativité des énoncés de la théorie économique : une approche conventionnaliste

open access: yesRevue de la Régulation, 2015
This thesis explores the analytical scope offered by the notion of performativity of economics. After having emphasize that its principal limit was its difficulty of provide a clear theorization of potential failures of performativity, we set a new ...
Nicolas Brisset
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

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