Results 61 to 70 of about 150,891 (266)

Cooperatives on Focus: The Case of Client Relation Practices in the Province of Cavite

open access: yesJournal of Education, Management and Development Studies
Cooperatives are valuable economic stimuli in the Philippines, contributing to fast economic growth since cooperatives can inject funds and resources that may use in the market.
Xavier Lawrence Mendoza   +3 more
doaj   +1 more source

Minimizing Medication Errors from Electronic Prescription Transmission—Digitizing Compounded Drug Preparations

open access: yesPharmacy, 2019
Lack of standardization related to compounded drug preparations, especially in the transition of care situations, threatens patient safety by facilitating medication error.
Richard H. Parrish   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Chorusing or questioning: Using EQs and KWLs in the science classroom in Anglophone Cameroon

open access: yesAfrican Journal of Teacher Education and Development
Background: Teacher-led recitation, choral responses, and rote learning are common in primary Science classrooms across sub-Saharan Africa. This study examines the impact of teacher training that implemented two pedagogical strategies, Essential ...
Susan Lowes   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Nicolas Brisset, Performativité des énoncés de la théorie économique : une approche conventionnaliste

open access: yesRevue de la Régulation, 2015
This thesis explores the analytical scope offered by the notion of performativity of economics. After having emphasize that its principal limit was its difficulty of provide a clear theorization of potential failures of performativity, we set a new ...
Nicolas Brisset
doaj   +1 more source

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