Results 71 to 80 of about 67,930 (230)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Application of functionally graded materials for severe plastic deformation and smart materials: experimental study and finite element analysis [PDF]

, 2012
Functionally graded materials (FGMs) refer to the composite materials where the compositions or the microstructures are locally varied so that a certain variation of the local material properties is achieved.
Jamian, Saifulnizan
core  

Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization [PDF]

, 2016
Objectives The aim of this study was to compare microvascular resistance under both baseline and hyperemic conditions immediately after percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) with an unobstructed reference vessel in ...
Alamgir, Farquad, Cunnington, Michael S., Hoye, Angela, Ladwiniec, Andrew, Rossington, Jennifer, Thackray, Simon   +5 more
core   +1 more source

Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43

Advanced Science, EarlyView.
Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang, Qi Wang, Ruolan Yan, Xiaochuan Wang, Jianlan Gu   +4 more
wiley   +1 more source

A bibliometric and social network analysis perspective of X‐ray phase‐contrast imaging in medical imaging

Journal of Medical Radiation Sciences, 2022
Introduction Phase‐contrast imaging (PCI) is a novel technology that can visualise variations in X‐ray refraction (phase contrast) in addition to differences in X‐ray attenuation (absorption contrast).
Jessica Tu, Patrick C. Brennan, Sarah Lewis, Seyedamir Tavakoli Taba   +3 more
doaj   +1 more source

Efficacy of virtual reality reducing anxiety during CTO revascularization: the ReViCTO trial design

REC: Interventional Cardiology (English Ed.), 2023
Introduction and objectives: Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) are long procedures where many patients suffer moderate-to-high level anxiety and pain.
Agustín Fernández-Cisnal, Beatriz Silla, José María Ramón, Ernesto Valero, Sergio García-Blas, Julio Núñez, Vicent Bodí, Juan Sanchis, Gema Miñana   +8 more
doaj   +1 more source

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

Advanced Science, EarlyView.
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang, Zhan‐Zhan Li, Shu‐Ding Sun, Ya‐Gang Song, Jin‐Xin Miao, Xiang‐Xiang Wu, Yong‐Li Han, Xiao‐Lei Zhang, Wen‐Jing Chen, Qing‐Hua Wang, Yu Zhang, Yiping Fu, Yu‐ting Liu, Lin‐yan Lang, Wen‐Xia Zhao, Ming‐San Miao   +15 more
wiley   +1 more source

Clinical Significance of Cys-C and hs-CRP in Coronary Heart Disease Patients Undergoing Percutaneous Coronary Intervention

Brazilian Journal of Cardiovascular Surgery
Objective: To investigate the clinical significance of serum cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) in coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI).
Zheng Tan, Li Li, Yi Ma, Xuebin Geng
doaj   +1 more source

Impact of assessment of fractional flow reserve and instantaneous wave-free ratio on clinical outcomes of percutaneous coronary intervention: a systematic review, meta-analysis and meta-regression analysis

Российский кардиологический журнал, 2023
Aim. To conduct a systematic review and meta-analysis to compare clinical outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) using conventional coronary angiography (CAG) or fractional flow reserve
E. Z. Golukhova, K. V. Petrosian, A. V. Abrosimov, N. I. Bulaeva, E. S. Goncharova, B. Sh. Berdibekov   +5 more
doaj   +1 more source

Parallel Multimodal Language Model: Enhanced Breast Nodule Diagnosis through Parallel Multimodal Representations and Large Language Models

Advanced Intelligent Systems, EarlyView.
This study introduces the Parallel Multimodal Language Model (PMLM), a multimodal diagnostic framework that integrates medical images and textual data to enhance early breast cancer detection. By addressing the limitations of text‐only large language models, PMLM significantly improves diagnostic performance.
Dashun Zheng, Patrick Cheong‐Iao Pang, Ping He, Yue Sun, Hongju Yan, Xiangyu Xiong, Ligang Cui, Tao Tan, Lingyun Bao   +8 more
wiley   +1 more source