Results 71 to 80 of about 6,286 (288)

Creating value(s) by integrating local and extra-local resources in cereal production in the Swiss Alps [PDF]

, 2020
This paper explores the long-term prospect of alternative, local food initiatives, taking a particular interest in the development of the embedded local values, understood as economic as well as cultural values.
Moschitz, Heidrun, Oehen, Bernadette
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Organic agriculture and sustainable practices: towards a typology of innovative farmers [PDF]

, 2014
This paper aims to identify the factors that influence the choice of organic farmers to innovate for more sustainable practices that go beyond the strict limits imposed by the certification.
Bocci, Riccardo, Brites, Claudia, Dinis, Isabel, Ortolani, Livia   +3 more
core   +3 more sources

English comparative constructions at different levels of schematicity: what is the role of adjective-specific variability?

Cognitive Linguistics
This study analyzes the English comparative alternation (morphological prouder and periphrastic more proud) with regard to adjective-specific variability. Substantial empirical evidence indicates that speakers redundantly represent both abstract schemas (
Hotta Hikaru, Hilpert Martin
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Herstellung eines Phaffia rhodozyma : Stamms mit verstärkter Astaxanthin-Synthese über gezielte genetische Modifikation chemisch mutagenisierter Stämme [PDF]

, 2014
Ziel dieser Arbeit war es erstmals durch eine Kombination aus chemischer Mutagenese und gezielter genetischer Modifikation (hier: „metabolic engineering“) einen Phaffia-Stamm herzustellen, welcher über die Mutagenese hinaus über eine weiter verstärkte ...
Gassel, Sören
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Data Mining with Shallow vs. Linguistic Features to Study Diversification of Scientific Registers [PDF]

, 2014
We present a methodology to analyze the linguistic evolution of scientific registers with data mining techniques, comparing the insights gained from shallow vs. linguistic features.
Degaetano-Ortlieb, Stefania, Fankhauser, Peter, Kermes, Hannah, Lapshinova-Koltunski, Ekaterina, Ordan, Noam, Teich, Elke   +5 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Between Conventionalization and Civic Agriculture: Emerging Trends in the Chilean Agroecological Movement

Journal of Agriculture, Food Systems, and Community Development, 2016
Chile has played a relevant role in neoliberal global food production since the 1980s, using the motto "Chile: An Agro-food Power." Thus, it is relevant to enquire about the exercise of individual and collective citizenship on the part of agricultural ...
Beatriz Cid-Aguayo
doaj   +1 more source