Results 71 to 80 of about 1,885 (297)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Towards a radically usage-based account of constructional attrition: integrating subtractive language developments in the Entrenchment-and-Conventionalization model

, 2022
This chapter reflects on how the gradual disappearance of a construction from a language can be accounted for in a radically usage-based diachronic construction grammar through an exploration of how the phenomenon can be accommodated in Schmid’s (2020 ...
Noel, D
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Feeling Phonology: The conventionalization of phonology in protactile communities in the United States

, 2020
A new phonological system is becoming conventional across a group of DeafBlind signers in the United States, who communicate via reciprocal, tactile channels--a practice known as Protactile .
Edwards, Terra, Brentari, Diane
core  

Converging evidence: Network structure effects on conventionalization of gestural referring expressions

, 2020
New languages emerge through interactions among people, yet the role of social network structure in language emergence is not clear, despite research from experimental semiotics, observational fieldwork, and computational modeling.
Pyeong Whan Cho, Marie Coppola, Matthew L Hall, Russell Richie   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The dynamics of the linguistic system : usage, conventionalization, and entrenchment /

, 2020
This volume outlines a model of language that can be characterized as functionalist, usage-based, dynamic, and complex-adaptive. The core idea is that linguistic structure is not stable and uniform, but continually refreshed by the interaction between ...
Schmid, Hans-Jörg(viaf)100288982
core  

English comparative constructions at different levels of schematicity: what is the role of adjective-specific variability?

Cognitive Linguistics
This study analyzes the English comparative alternation (morphological prouder and periphrastic more proud) with regard to adjective-specific variability. Substantial empirical evidence indicates that speakers redundantly represent both abstract schemas (
Hotta Hikaru, Hilpert Martin
doaj   +1 more source

Review of the collective monograph “The Metalanguage of cognitive linguistics (revisiting complex self-developing systems)” by S.N. Bredikhin, M.V. Kamensky, G.N. Manaenko, et al. (Stavropol: North Caucasus Federal University, 2024) [PDF]

Актуальные проблемы филологии и педагогической лингвистики
The monograph is a comprehensive study of the means of metalinguistic description in cognitive linguistics. The cornerstone of building a holistic metalinguistic system of the transdisciplinary field of cognitive linguistics is the continuity of ...
Gennady G. Slyshkin
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source