Results 91 to 100 of about 3,720,590 (347)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao   +7 more
wiley   +1 more source

Label-free detection of γ-aminobutyric acid based on silicon nanowire biosensor

open access: yesNano Convergence, 2019
γ-Aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system (CNS), which acts as a major biomarker for neurological disorders such as Parkinson’s disease and Meningitis.
Jin-Ho Lee   +3 more
doaj   +1 more source

Continuous convergence and preservation of convergences of sets

open access: yesJournal of Mathematical Analysis and Applications, 1986
Let \(\Sigma\), T, and \(\Theta\) be convergences on \(2^ X\) (the space of subsets of X), \(2^ Y\), and \(2^{X\times Y}\) (the space of multifunctions from X to Y), respectively. The authors are interested only in those convergences \(\Theta\) with the following property: if a filtered family \({\mathcal A}\) of sets converges to A in \((2^ X,\Sigma)\)
M. B. Lignola   +3 more
openaire   +3 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

open access: yesFEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui   +3 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

open access: yesFEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Interest Convergence, Intersectionality, and Counter-Storytelling: Critical Race Theory as Practice in Scholarly Communications Librarianship

open access: yesIn the Library with the Lead Pipe
Despite diversity, equity, and inclusion (DEI) rhetoric in librarianship, library workers who are Black, Indigenous, and people of color (BIPOC) are still underrepresented and marginalized.
Maria Mejia, Anastasia Chiu
doaj  

Photocatalytic and electrocatalytic approaches towards atmospheric nitrogen reduction to ammonia under ambient conditions

open access: yesNano Convergence, 2019
Ammonia production is essential for sustaining the demand for providing food for the growing population. Being a great source of hydrogen, it has significant potential in turning out to be a viable candidate for the future hydrogen economy. Ammonia has a
Jude John, Dong-Kyu Lee, Uk Sim
doaj   +1 more source

Convergence of the $k$-Means Minimization Problem using $\Gamma$-Convergence

open access: yes, 2015
The $k$-means method is an iterative clustering algorithm which associates each observation with one of $k$ clusters. It traditionally employs cluster centers in the same space as the observed data.
Cade, Neil   +3 more
core  

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