Results 191 to 200 of about 8,356 (228)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Molecular phylogeny and species delimitation unravel climate-driven diversification and cryptic radiation in Iranian steppe Vipers (Vipera ursinii-renardi complex). [PDF]

Sci Rep
Faridi M, Jozi SA, Zaeimdar M, Nazarizadeh M, Kaboli M.   +4 more
europepmc   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

LLM-Assessed Relatedness of Microbiome Study Descriptions Aligns more Strongly with Functional than with Taxonomic Profile Similarity. [PDF]

Microb Ecol
Venetsianou NK, Paragkamian S, Kalaentzis K, Loukas A, Damianou C, Lagani V, Jensen LJ, Pafilis E.   +7 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Hybrid multiscale forecasting of SRU sulfur gas concentrations using VMD CEEMDAN and optimized PatchTST. [PDF]

iScience
Sun W, Li L, Lu B, Jiang L, Zhang J.
europepmc   +1 more source

TimesNet-BFT: Mitigating Network State Uncertainty in Byzantine Consensus via Deep Temporal Modeling. [PDF]

Entropy (Basel)
Wang H, Liu H, Liu Y, Ma H, Gao P.
europepmc   +1 more source

Phylogenetic and Divergence Time Estimation of Muscomorpha with Low-Coverage Whole-Genome Sequencing of Syrphidae (Diptera: Brachycera). [PDF]

Biology (Basel)
Liao C, Li H, Gao Z, Yan W, Ji Y.
europepmc   +1 more source

Dao Yin practice for student wellbeing: a classroom-based pilot study. [PDF]

Front Psychol
Zhao J, Zheng Z, Li Y.
europepmc   +1 more source

Calibrating and documenting host-switching and evolution of incompatibility loci for two closely related Wolbachia clades. [PDF]

Genetics
Shropshire JD, Conner WR, Vanderpool D, Hoffmann AA, Turelli M, Cooper BS.   +5 more
europepmc   +1 more source