Results 31 to 40 of about 144,979 (262)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

EU enlargement: Does economics of regional integration matter? [PDF]

open access: yesZbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2018
For stability and advance of the EU and prospective member countries, it is important to assess the best time for new enlargement. In this paper, we have tested a number of macroeconomic and macro-financial variables in order to check whether a number
Srđan Marinković   +2 more
doaj   +1 more source

Convergence Criteria of Three Step Schemes for Solving Equations

open access: yesMathematics, 2021
We develop a unified convergence analysis of three-step iterative schemes for solving nonlinear Banach space valued equations. The local convergence order has been shown before to be five on the finite dimensional Euclidean space assuming Taylor ...
Samundra Regmi   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

ANALYSIS OF BUDGET DEFICIT AND ITS PROBLEMS IN LITHUANIA

open access: yesВісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015
Budget deficit is one of the most important parts of macroeconomics. Since 1990, the government of the Lithuanian Republic has been faced with problems in balancing the budget deficit; most of the years, the country’s budget was deficit with the lack of ...
F. Jaseviciene, E. Rudzionyte
doaj   +1 more source

The Effect of Inadequate Convergence Criteria in Automatic Routines [PDF]

open access: yesThe Computer Journal, 1969
'The aim of an automatic integration scheme is to relieve the person who has to compute an integral-[the user] of any need to think.' This is the opening sentence of Chapter 6, 'Automatic Integration' of the standard textbook Numerical Integration, by P. Davis and P. Rabinowitz (1967).
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

ISSUES REGARDING THE NOMINAL CONVERGENCE CRITERIA FOR JOINING THE EURO AREA [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2020
Romania, a member state of the European Union, has committed itself to adopting the euro under the Treaty on the Functioning of the European Union, which means meeting nominal and real convergence criteria, as well as achieving parameters for the ...
ALINA NIȚESCU
doaj  

Home - About - Disclaimer - Privacy