Results 61 to 70 of about 261,314 (251)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

ECE cipher: Enhanced convergent encryption for securing and deduplicating public cloud data

The Scientific Temper
Cloud computing offers scalable and cost-effective storage solutions, but concerns over data security, unauthorized access, and storage inefficiencies remain significant. Data deduplication is crucial in reducing storage costs by eliminating redundant copies, yet traditional encryption methods hinder deduplication by generating unique ciphertexts for ...
Priya Nandhagopal, Jayasimman Lawrence
openaire   +1 more source

Secure Cloud Storage: A Framework for Data Protection as a Service in the Multi-cloud Environment [PDF]

, 2015
This paper introduces Secure Cloud Storage (SCS), a framework for Data Protection as a Service (DPaaS) to cloud computing users. Compared to the existing Data Encryption as a Service (DEaaS) such as those provided by Amazon and Google, DPaaS provides ...
Colombo, Maurizio, Sajjad, Ali, Theo Dimitrakos, Ali Sajjad, Dimitrakos, Theo, Vu, Quang, Rasool Asal, Fadi Ali El-Moussa, Asal, Rasool, Maurizio Colombo, Quang Hieu Vu, El-Moussa, Fadi Ali   +11 more
core   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

The Lord of the Shares: Combining Attribute-Based Encryption and Searchable Encryption for Flexible Data Sharing

, 2019
Secure cloud storage is considered one of the most important issues that both businesses and end-users are considering before moving their private data to the cloud.
Michalas, A.
core   +1 more source

dynoGP: Deep Gaussian Processes for Dynamic System Identification

International Journal of Adaptive Control and Signal Processing, EarlyView.
This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli, Marco Forgione, Dario Piga, Marco Zaffalon   +3 more
wiley   +1 more source

Optimal Asymmetric Data Encryption Algorithm [PDF]

, 2021
Today public-key cryptosystems are particularly vulnerable to fetching cipher text and adaptively matched plaintext attacks To prevent such attacks in practice optimal asymmetric algorithms are used for example RSA-OAEP and etc In this article ...
Kuryazov D.M.
core  

Assessment of Numerical Method by Experimental Data for Integrated Hypersonic Vehicles

Journal of Applied Fluid Mechanics, 2019
This paper addresses the problem of rapid aerodynamic assessment and experimental verification of integrated hypersonic vehicles. Based on the adaptive Cartesian grid system, the aerodynamic performance of the air-breathing hypersonic vehicle is ...
X. Wen, J. Liu, Z. Liu, Z. Xia, L. Jin
doaj  

Fostering Innovation: Streamlining Magnetocaloric Materials Research by Digitalization

Advanced Engineering Materials, EarlyView.
Magnetocaloric cooling (MCE) is an environmentally friendly refrigeration method with great potential. Optimizing MCE materials involves the preparation and screening of large quantities of samples, which in turn generates a large amount of data. A digitalization approach is presented that uses ontologies, knowledge graphs, and digital workflows to ...
Simon Bekemeier, Moritz Blum, Luana Caron, Alisa Chirkova, Philipp Cimiano, Basil Ell, Inga Ennen, Michael Feige, Maik Gaerner, Thomas Hilbig, Andreas Hütten, Günter Reiss, Tapas Samanta, Sonja Schöning, Christian Schröder, Lennart Schwan, Chris Taake, Martin Wortmann   +17 more
wiley   +1 more source

Is an Apple an Orange? A Large Language Model Benchmark for Candidate Term Extraction and Subclass Decisions Against Upper Ontologies in Engineering and Materials Science

Advanced Engineering Materials, EarlyView.
Building machine‐readable vocabularies for materials science is slow, expert‐driven work. This study benchmarks 13 large language models on two of its first steps: finding candidate terms in engineering articles and deciding where they belong in a class hierarchy.
Thomas Bjarsch, Maximilian Holland, Klaus Drechsler, Johannes Schilp   +3 more
wiley   +1 more source