Results 51 to 60 of about 33,666 (253)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Continuous adaptation of conversation aids for uterine fibroids treatment options in a four-year multi-center implementation project

BMC Medical Informatics and Decision Making
Background Fibroids are non-cancerous uterine growths that can cause symptoms impacting quality of life. The breadth of treatment options allows for patient-centered preference.
Danielle Schubbe, Marie-Anne Durand, Rachel C. Forcino, Jaclyn Engel, Marisa Tomaino, Monica Adams-Foster, Carla Bacon, Carrie Cahill Mulligan, Sateria Venable, Tina Foster, Paul J. Barr, Raymond M. Anchan, Shannon Laughlin-Tommaso, Anne Lindholm, Maya Seshan, Rossella M. Gargiulo, Patricia Stephenson, Karen George, Mobolaji Ajao, Tessa Madden, Erika Banks, Antonio R. Gargiulo, James O’Malley, Maria van den Muijsenbergh, Johanna W. M. Aarts, Glyn Elwyn   +25 more
doaj   +1 more source

EFFECTS OF MEMORY AIDS ON THE DYADIC CONVERSATIONS OF INDIVIDUALS WITH DEMENTIA [PDF]

Journal of Applied Behavior Analysis, 1993
The effects of a prosthetic memory aid on the conversational content and social skills of dyads with dementia were evaluated. Six individuals with moderate to severe dementia served as either subject or partner in dyads during 5‐min conversational probes conducted three times per week in daycare and nursing‐home settings.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The UPFRONT project: tailored implementation and evaluation of a patient decision aid to support shared decision-making about management of symptomatic uterine fibroids

Implementation Science
Objective To evaluate implementation of a patient decision aid for symptomatic uterine fibroid management to improve shared decision-making at five clinical settings across the United States.
Rachel C. Forcino, Marie-Anne Durand, Danielle Schubbe, Jaclyn Engel, Erika Banks, Shannon K. Laughlin-Tommaso, Tina Foster, Tessa Madden, Raymond M. Anchan, Mary Politi, Anne Lindholm, Rossella M. Gargiulo, Maya Seshan, Marisa Tomaino, Jingyi Zhang, Stephanie C. Acquilano, Sade Akinfe, Anupam Sharma, Johanna W. M. Aarts, Glyn Elwyn   +19 more
doaj   +1 more source

Cooperativism as pedagogy: Conversation with Gustavo Machado a lecturer and researcher from Facultad de Ciencias Sociales de la Universidad de la República

Radical Housing Journal
This conversation with Gustavo Machado discusses the role of cooperativism as a pedagogical process in Uruguay. Machado emphasizes how cooperatives serve as models for housing production and transformative social learning processes, embedding ...
Gustavo Machado, Ana Vilenica, Moisés Quiroz   +2 more
doaj   +1 more source

Gene Conversion may aid Adaptive Peak Shifts

Journal of Theoretical Biology, 2000
Gene conversion is often viewed as a homogenizing force that opposes adaptive evolution. The objective of this study is to suggest a potential role for gene conversion in adaptive evolution of proteins through aiding the transfer of a population from one adaptive peak to another. Our hypothesis starts with the observation that a tandem gene duplication
T F, Hansen, A J, Carter, C H, Chiu
openaire   +2 more sources

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source