Results 111 to 120 of about 1,251,822 (219)

The direct conversion of strictosamide to pumiloside <i>in planta</i> expands the camptothecin biosynthetic pathway. [PDF]

Synth Syst Biotechnol
Li Y, Wu Z, Chen J, Ruan Q, Yao L, Shao L, Hao X, Kai G.   +7 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Conversion from failed antireflux surgery to RefluxStop: A multicenter feasibility, technical evaluation, safety, and effectiveness study with 30 consecutive cases. [PDF]

Langenbecks Arch Surg
Lehmann TG, Zehetner J.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Conversion surgery after response to zolbetuximab-based chemotherapy in Claudin 18.2-positive gastric cancer: a case report. [PDF]

J Surg Case Rep
Ohno S, Suetsugu T, Takeuchi H, Miyazaki S, Kawahara T, Yamamoto K, Kiriyama S, Tawada K, Iwata Y, Komori S, Tanaka C, Nagao N, Kawai M.   +12 more
europepmc   +1 more source

The Use of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio and Platelets-to-Lymphocyte Ratio in the Assessment of the Risk of Conversion and Complications After Cholecystectomy Performed Due to Symptomatic Cholelithiasis

Therapeutics and Clinical Risk Management
Bartosz Molasy,1,2 Mateusz Frydrych,2 Aldona Kubala-Kukuś,3 Stanisław Głuszek1 1Collegium Medicum, The Jan Kochanowski University, Kielce, Poland; 2Department of General Surgery, St Alexander Hospital, Kielce, Poland; 3Institute of ...
Molasy B, Frydrych M, Kubala-Kukuś A, Głuszek S   +3 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification. [PDF]

Immunogenetics
Pinto JEL, Gervásio JHB, Ng JC, Gomes-Silva A, de Matos Guedes HL, Cunha L, Castilho LR, da Silva JL, Franco GR, Navas C, Felicori LF.   +10 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The magic of first impressions: Do facial displays on online platforms affect users' offline conversion rate? [PDF]

PLoS One
Zhang X, Li Q, Han C, Huang X.
europepmc   +1 more source