Results 111 to 120 of about 1,641,962 (296)

Accommodation, Fortification, or Conversion? Approaches to Catholic Engagement with Secular Culture

Religions
As the Catholic Church declines in the west, critical questions are raised about its engagement with secular culture. Different engagement models have been experimented with since the 1960s, which I term accommodation, fortification, and conversion. Each
Hannah Vaughan-Spruce
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Knowledge-driven semantic converting method of multimodal models toward a geospatial perspective

Geo-spatial Information Science
In the virtual geographic environment, conducting status analysis on urban structures and similar objects is crucial for enhancing their detailed management level.
Jianbo Lai, Jun Zhu, Pei Dang, Jianlin Wu, Yukun Guo, Xinyu Yang, Na Li   +6 more
doaj   +1 more source

Uncertainties in the calibrations of star formation rate

, 2013
The calibrations of star formation rate (SFR) are prone to be affected by many factors, such as metallicity, initial mass function (IMF), evolutionary population synthesis (EPS) models and so on.
Han, Zhanwen, Kang, Xiaoyu, Li, Lifang, Zhang, Fenghui, Zhuang, Yulong   +4 more
core   +1 more source

Modeling Empathetic Alignment in Conversation

Proceedings of the 2024 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies (Volume 1: Long Papers)
Empathy requires perspective-taking: empathetic responses require a person to reason about what another has experienced and communicate that understanding in language. However, most NLP approaches to empathy do not explicitly model this alignment process.
Jiamin Yang, David Jurgens
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Coupled memory sampled-data control for fractional stochastic wind energy conversion models

International Journal of Electrical Power & Energy Systems
This study aims to design a coupled memory sampled-data control (CMSDC) for fractional stochastic wind energy conversion systems (WECSs). Theoretically, this paper introduces a permanent magnet synchronous generator (PMSG)-based WECS, which is crucial in
Girija Panneerselvam, Prakash Mani
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source