Results 61 to 70 of about 2,270,246 (347)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Swiss Monitoring of Potential Organ Donors (SwissPOD): a prospective 12-month cohort study of all adult ICU deaths in Switzerland

Swiss Medical Weekly, 2014
BACKGROUND: The Swiss Monitoring of Potential Organ Donors (SwissPOD) was initiated to investigate the causes of the overall low organ donation rate in Switzerland. The objective of our study was an assessment of the donation after brain death (DBD)
Julius H. Weiss, Isabelle Keel, Franz F. Immer, Jan Wiegand, Christoph Haberthür, Comité National du Don d’Organes (CNDO)   +5 more
doaj   +1 more source

Laparoscopic Cholecystectomy Conversion Rates Two Decades Later [PDF]

JSLS : Journal of the Society of Laparoendoscopic Surgeons, 2010
Now nearly 2 decades into the laparoscopic era, nationwide laparoscopic cholecystectomy conversion rates remain around 5% to 10%. We analyzed patient- and surgeon-specific factors that may impact the decision to convert to open.We retrospectively analyzed 2205 LCs performed at a large tertiary community hospital over a 52 month period (May 2004 through
Sakpal, Sujit Vijay, Bindra, Supreet Singh, Chamberlain, Ronald S.   +2 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Review of video frame rate up conversion detection

网络与信息安全学报, 2018
Video frame rate up-conversion detection technology is a kind of video forensics technology.In order to systematically elaborate the research progress in the field of video up-conversion detection and guide the follow-up research of video up-conversion ...
Tianqi HE, Xinghao JIANG,Tanfeng SUN
doaj   +3 more sources

Effect of different interventions on the treatment of high-risk human papillomavirus infection: a systematic review and network meta-analysis

Frontiers in Medicine
BackgroundPersistent infection with high-risk human papillomavirus (HR-HPV) can lead to cervical intraepithelial neoplasia and cancer. At present, there is no medication that specifically targets HR-HPV infection.ObjectiveThis study aimed to evaluate the
Dong-Yue Wang, Dong-Yue Wang, Ying-Ying Cui, Wei-Wei Zhang, Meng-Si Fan, Ke-Xin Qiu, Li Yan   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Impact of Television Advertising for Freemium Services on Consumer Purchases:

Maketingu rebyu
In freemium platforms where the basic usage fee is free, operators have the advantage of acquiring users without incurring advertising costs. However, Japanese operators often place TV advertisements, which are generally considered to be expensive ...
Yuichi Enosawa
doaj   +1 more source

Laparoscopic cholecystectomy: Conversion rate and complcation

Journal of Society of Surgeons of Nepal, 2016
Introduction and Objective: Laparoscopic Cholecystectomy is the standard surgical treatment for gallbladder disease. However, conversion to open surgery is not the complication.
BR Malla, HN Joshi, N Rajbhandari, YR Shakya, B Karki, D Gyanwali, S Shrestha, R Koju   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source